Publications by authors named "Christopher B Doering"

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Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A.
Alok Srivastava, Aby Abraham, Fouzia Aboobacker, Gurbind Singh, Tulasi Geevar, Christopher B Doering

N Engl J Med· January 2025

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Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain.
Kenneth C Childers, Ben Cowper, Jordan D Vaughan, Juliet R McGill, Omar Davulcu, Christopher B Doering

J Thromb Haemost· September 2024

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Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction.
Christopher W Coyle, Kristopher A Knight, Harrison C Brown, Stephan N George, Gabriela Denning, Christopher B Doering

J Thromb Haemost· March 2024

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Directing the migration of serum-free, -expanded Vγ9Vδ2 T cells.
Kiran K Parwani, Gianna M Branella, Rebecca E Burnham, Andre J Burnham, Austre Y Schiaffino Bustamante, Christopher B Doering

Front Immunol· March 2024

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Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia.
Gianna M Branella, Jasmine Y Lee, Jennifer Okalova, Kiran K Parwani, Jordan S Alexander, Christopher B Doering

Front Immunol· December 2023

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Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor.
Kenneth C Childers, Nathan G Avery, Kevin A Estrada Alamo, Omar Davulcu, Rose Marie Haynes, Christopher B Doering

Blood· July 2023

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Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity.
Martin Rodriguez, Brady Trevisan, Ritu M Ramamurthy, Sunil K George, Jonathan Diaz, Christopher B Doering

Nat Commun· July 2023

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Identification and targeting of protein tyrosine kinase 7 (PTK7) as an immunotherapy candidate for neuroblastoma.
Jasmine Y Lee, Hunter C Jonus, Arhanti Sadanand, Gianna M Branella, Victor Maximov, Christopher B Doering

Cell Rep Med· June 2023

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Enhancing the effectiveness of γδ T cells by mRNA transfection of chimeric antigen receptors or bispecific T cell engagers.
Scott A Becker, Brian G Petrich, Bing Yu, Kristopher A Knight, Harrison C Brown, Christopher B Doering

Mol Ther Oncolytics· June 2023

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Comparison of different gene addition strategies to modify placental derived-mesenchymal stromal cells to produce FVIII.
Ritu M Ramamurthy, Martin Rodriguez, Hannah C Ainsworth, Jordan Shields, Diane Meares, Christopher B Doering

Front Immunol· January 2023

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SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa.
Kenneth C Childers, Shaun C Peters, Pete Lollar, Harold Trent Spencer, Christopher B Doering

Blood Adv· June 2022

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Neutralizing Antibodies Against Factor VIII Can Occur Through a Non-Germinal Center Pathway.
Seema R Patel, Taran S Lundgren, Wallace Hunter Baldwin, Courtney Cox, Ernest T Parker, Christopher B Doering

Front Immunol· June 2022

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Thrombopoietin-based CAR-T cells demonstrate in vitro and in vivo cytotoxicity to MPL positive acute myelogenous leukemia and hematopoietic stem cells.
Jaquelyn T Zoine, Chengyu Prince, Jamie Y Story, Gianna M Branella, Allison M Lytle, Christopher B Doering

Gene Ther· May 2022

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Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice.
Taran S Lundgren, Gabriela Denning, Sean R Stowell, H Trent Spencer, Christopher B Doering

Blood Adv· April 2022

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Dissecting the cellular components of γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials.
Hunter C Jonus, Rebecca E Burnham, Andrew Ho, Adeiye A Pilgrim, Jenny Shim, Christopher B Doering

Oncoimmunology· April 2022

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Nonhuman glycans can regulate anti-factor VIII antibody formation in mice.
Connie M Arthur, Patricia E Zerra, Sooncheon Shin, Jianmei Wang, Xeuzheng Song, Christopher B Doering

Blood· March 2022

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Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor.
Estelle K Ronayne, Shaun C Peters, Joseph S Gish, Celena Wilson, H Trent Spencer, Christopher B Doering

Front Immunol· December 2021

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Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette.
Sandeep R P Kumar, Jun Xie, Shilang Hu, Jihye Ko, Qifeng Huang, Christopher B Doering

Mol Ther Methods Clin Dev· December 2021

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Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction.
Kristopher A Knight, Christopher W Coyle, Caelan E Radford, Ernest T Parker, Andrew Fedanov, Christopher B Doering

Blood Adv· September 2021

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Investigating Optimal Autologous Cellular Platforms for Prenatal or Perinatal Factor VIII Delivery to Treat Hemophilia A.
Christopher Stem, Christopher Rodman, Ritu M Ramamurthy, Sunil George, Diane Meares, Christopher B Doering

Front Cell Dev Biol· August 2021

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F5-Atlanta: A novel mutation in F5 associated with enhanced East Texas splicing and FV-short production.
Karen L Zimowski, Teodolinda Petrillo, Michelle D Ho, Julie Wechsler, Jordan E Shields, Christopher B Doering

J Thromb Haemost· July 2021

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Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII.
Athena L Russell, Chengyu Prince, Taran S Lundgren, Kristopher A Knight, Gabriela Denning, Christopher B Doering

Mol Ther Methods Clin Dev· June 2021

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Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.
Joseph S Gish, Lexi Jarvis, Kenneth C Childers, Shaun C Peters, Connor S Garrels, Christopher B Doering

Blood· May 2021

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Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A.
Brady Trevisan, Alshaimaa Morsi, Julio Aleman, Martin Rodriguez, Jordan Shields, Christopher B Doering

Front Bioeng Biotechnol· March 2021

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Molecular coevolution of coagulation factor VIII and von Willebrand factor.
Philip M Zakas, Christopher W Coyle, Anja Brehm, Marion Bayer, Barbara Solecka-Witulska, Christopher B Doering

Blood Adv· February 2021

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