Publications by authors named "Christopher Bigge"

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Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
Agustin Casimiro-Garcia, Ronald J Heemstra, Christopher F Bigge, Jing Chen, Fred A Ciske

Bioorg Med Chem Lett· February 2013

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Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.
Agustin Casimiro-Garcia, Gary F Filzen, Declan Flynn, Christopher F Bigge, Jing Chen

J Med Chem· June 2011

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Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.
Agustin Casimiro-Garcia, Christopher F Bigge, Jo Ann Davis, Teresa Padalino, James Pulaski

Bioorg Med Chem· October 2009

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Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Hao Chen, Michael Zientek, Mehran Jalaie, Yanhua Zhang, Christopher Bigge

Chem Res Toxicol· September 2009

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Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.
Chad A Van Huis, Agustin Casimiro-Garcia, Christopher F Bigge, Wayne L Cody, Danette A Dudley

Bioorg Med Chem· March 2009

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Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats.
Hao Chen, Yanhua Zhang, Jeremy Edmunds, Christopher Bigge, Abdul Mutlib

Chem Res Toxicol· May 2008

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Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.
Agustin Casimiro-Garcia, Christopher F Bigge, Jo Ann Davis, Teresa Padalino, James Pulaski

Bioorg Med Chem· May 2008

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The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor.
Jeffrey T Kohrt, Christopher F Bigge, John W Bryant, Agustin Casimiro-Garcia, Liguo Chi

Chem Biol Drug Des· August 2007

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Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors.
Chad A Van Huis, Christopher F Bigge, Agustin Casimiro-Garcia, Wayne L Cody, Danette A Dudley

Chem Biol Drug Des· June 2007

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The discovery of glycine and related amino acid-based factor Xa inhibitors.
Jeffrey T Kohrt, Kevin J Filipski, Wayne L Cody, Christopher F Bigge, Frances La

Bioorg Med Chem· July 2006

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Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands.
Raymond A Hudack, Nancy S Barta, Chuangxing Guo, Judith Deal, Liming Dong, Christopher Bigge

J Med Chem· February 2006

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Improved intestinal transport of PD 158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters.
Doo-Man Oh, Hyo-Kyung Han, Rufus M Williamson, Christopher F Bigge, Gordon L Amidon

J Pharm Sci· December 2002

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