Publications by authors named "Abdul Mutlib"

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E
Exploring the wave's structures to the nonlinear coupled system arising in surface geometry.
Khizar Farooq, Ejaz Hussain, Usman Younas, Herbert Mukalazi, Tamer M Khalaf, Abdul Mutlib

Sci Rep· April 2025

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Evaluation of absorption, distribution, metabolism, and excretion of [C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors.
Mingxiang Liao, Simon Watkins, Eileen Nash, Jeff Isaacson, Jeff Etter, Abdul Mutlib

Invest New Drugs· June 2020

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Application of Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).
Elias C Padilha, Jianyao Wang, Ed Kerns, Arthur Lee, Wenwei Huang, Abdul Mutlib

Front Pharmacol· April 2019

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Pharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits.
Vidmantas Petraitis, Ruta Petraitiene, Bo Bo W Maung, Farehin Khan, Ieva Alisauskaite, Abdul Mutlib

Antimicrob Agents Chemother· September 2018

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A
Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies.
Abdul Mutlib, Robert Espina, James Atherton, Jianyao Wang, Rasmy Talaat

Chem Res Toxicol· March 2012

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Application of quantitative NMR in pharmacological evaluation of biologically generated metabolites: implications in drug discovery.
Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen

Drug Metab Dispos· January 2011

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C
Characterization of HKI-272 covalent binding to human serum albumin.
Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Abdul Mutlib

Drug Metab Dispos· July 2010

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B
Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
Hao Chen, Scott Grover, Linning Yu, Gregory Walker, Abdul Mutlib

Chem Res Toxicol· January 2010

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C
Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Hao Chen, Michael Zientek, Mehran Jalaie, Yanhua Zhang, Christopher Bigge, Abdul Mutlib

Chem Res Toxicol· September 2009

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Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.
Robert Espina, Linning Yu, Jianyao Wang, Zeen Tong, Sarvesh Vashishtha, Abdul Mutlib

Chem Res Toxicol· February 2009

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Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.
Karthick Vishwanathan, Kathlene Babalola, Jack Wang, Robert Espina, Linning Yu, Abdul Mutlib

Chem Res Toxicol· February 2009

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Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of beta-oxidation in mice.
Zhi Liu, Abdul E Mutlib, Jianyao Wang, Rasmy E Talaat

Rapid Commun Mass Spectrom· November 2008

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Application of stable isotope-labeled compounds in metabolism and in metabolism-mediated toxicity studies.
Abdul E Mutlib

Chem Res Toxicol· September 2008

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B
Bioactivation of a dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide) scaffold to a putative p-chlorophenyl isocyanate in rat liver microsomes and in vivo in rats.
Hao Chen, Yanhua Zhang, Jeremy Edmunds, Christopher Bigge, Abdul Mutlib

Chem Res Toxicol· May 2008

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A
A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
Amit S Kalgutkar, James Driscoll, Sabrina X Zhao, Gregory S Walker, Richard M Shepard, Abdul E Mutlib

Chem Res Toxicol· December 2007

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Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey.
J Scott Daniels, Robert Espina, Kevin Cao, Haodan Yuan, Jianrong Lin, Abdul Mutlib

Chem Res Toxicol· November 2007

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Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
Seva E Kostrubsky, Stephen C Strom, Ewa Ellis, Sidney D Nelson, Abdul E Mutlib

Chem Res Toxicol· October 2007

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Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists.
Jared B J Milbank, Christopher S Knauer, Corinne E Augelli-Szafran, Annette T Sakkab-Tan, Kristin K Lin, Abdul E Mutlib

Bioorg Med Chem Lett· August 2007

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Application of in-line liquid chromatography-accurate radioisotope counting-mass spectrometry (LC-ARC-MS) to evaluate metabolic profile of [3H]-mefenamic acid in rat plasma.
Wing Lam, Cho-Ming Loi, James Atherton, Wayne Stolle, John Easter, Abdul Mutlib

Drug Metab Lett· August 2007

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Determination of degradation pathways and kinetics of acyl glucuronides by NMR spectroscopy.
Gregory S Walker, James Atherton, Jonathan Bauman, Christopher Kohl, Wing Lam, Abdul Mutlib

Chem Res Toxicol· June 2007

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Identification of potential genomic biomarkers of hepatotoxicity caused by reactive metabolites of N-methylformamide: Application of stable isotope labeled compounds in toxicogenomic studies.
Abdul Mutlib, Ping Jiang, Jim Atherton, Leslie Obert, Seva Kostrubsky

Chem Res Toxicol· October 2006

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Metabolism-dependent mutagenicity of a compound containing a piperazinyl indazole motif: Role of a novel p450-mediated metabolic reaction involving a putative oxaziridine intermediate.
Hao Chen, Joel Murray, Brian Kornberg, Lloyd Dethloff, David Rock, Abdul E Mutlib

Chem Res Toxicol· October 2006

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K
Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity.
Abdul E Mutlib, Theunis C Goosen, Jonathan N Bauman, J Andrew Williams, Shaila Kulkarni

Chem Res Toxicol· May 2006

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Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.
Seva E Kostrubsky, Stephen C Strom, Amit S Kalgutkar, Shaila Kulkarni, James Atherton, Abdul E Mutlib

Toxicol Sci· April 2006

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A
Application of on-line electrochemical derivatization coupled with high-performance liquid chromatography electrospray ionization mass spectrometry for detection and quantitation of (p-chlorophenyl)aniline in biological samples.
Hao Chen, Yanhua Zhang, Abdul E Mutlib, Min Zhong

Anal Chem· April 2006

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