Publications by authors named "Linning Yu"

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Characterization of HKI-272 covalent binding to human serum albumin.
Jianyao Wang, Xiao Xian Li-Chan, Jim Atherton, Lin Deng, Robert Espina, Linning Yu

Drug Metab Dispos· July 2010

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Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
Hao Chen, Scott Grover, Linning Yu, Gregory Walker, Abdul Mutlib

Chem Res Toxicol· January 2010

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Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.
Robert Espina, Linning Yu, Jianyao Wang, Zeen Tong, Sarvesh Vashishtha

Chem Res Toxicol· February 2009

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Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.
Karthick Vishwanathan, Kathlene Babalola, Jack Wang, Robert Espina, Linning Yu

Chem Res Toxicol· February 2009

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A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
Amit S Kalgutkar, James Driscoll, Sabrina X Zhao, Gregory S Walker, Richard M Shepard, Linning Yu

Chem Res Toxicol· December 2007

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Efficient use of the iron ortho-nitrophenylporphyrin chloride to mimic biological oxidations of dimethylaminoantipyrine.
Marc J Bazin, Helen Shi, Jeannine Delaney, Billie Kline, Zhendong Zhu, Linning Yu

Chem Biol Drug Des· October 2007

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Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouse.
Hani Zaher, Anis A Khan, Joe Palandra, Timothy G Brayman, Linning Yu

Mol Pharm· June 2006

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Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.
Linning Yu, Hong Liu, Wenkui Li, Fagen Zhang, Connie Luckie

Chem Res Toxicol· July 2004

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Equine estrogen metabolite 4-hydroxyequilenin induces anchorage-independent growth of human mammary epithelial MCF-10A cells: differential gene expression.
Muriel Cuendet, Xuemei Liu, Emily Pisha, Yan Li, Jiaqin Yao, Linning Yu

Mutat Res· June 2004

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Quinoids formed from estrogens and antiestrogens.
Judy L Bolton, Linning Yu, Gregory R J Thatcher

Methods Enzymol· April 2004

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Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase.
Yan Li, Jiaqin Yao, Minsun Chang, Dejan Nikolic, Linning Yu

Chem Res Toxicol· April 2004

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Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.
Violeta Toader, Xudong Xu, Adrian Nicolescu, Linning Yu, Judy L Bolton

Chem Res Toxicol· October 2003

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Identification of novel electrophilic metabolites of piper methysticum Forst (Kava).
Benjamin M Johnson, Sheng-Xiang Qiu, Shide Zhang, Fagen Zhang, Joanna E Burdette, Linning Yu

Chem Res Toxicol· June 2003

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