Publications by authors named "John Easter"

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Synthesis of a dual carbon-14-labeled calcitonin gene-related peptide receptor antagonist for use in a human absorption-distribution-metabolism-elimination study.
Wesley A Turley, John A Easter, Richard C Burrell, Samuel J Bonacorsi

J Labelled Comp Radiopharm· May 2022

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Synthesis of tritium labeled 30-KDa PEG and conjugation to form [ H]Pegbelfermin.
John A Easter, Yuan Tian, Richard C Burrell, Yang Hong, Samuel J Bonacorsi

J Labelled Comp Radiopharm· October 2021

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LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions.
Rasa Santockyte, Hamza Kandoussi, Weiqi Chen, Naiyu Zheng, Lata Venkatarangan, John Easter

Bioanalysis· September 2018

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Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
Alicia Regueiro-Ren, Jacob J Swidorski, Zheng Liu, Yan Chen, Ny Sin, John Easter

J Med Chem· August 2018

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UHPLC-MS/MS bioanalysis of human plasma coproporphyrins as potential biomarkers for organic anion-transporting polypeptide-mediated drug interactions.
Hamza Kandoussi, Jianing Zeng, Kumar Shah, Patricia Paterson, Rasa Santockyte, John Easter

Bioanalysis· May 2018

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Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.
Jiachang Gong, Timothy Eley, Bing He, Vinod Arora, Thomas Philip, John Easter

Xenobiotica· October 2016

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Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Wenying Li, Weiping Zhao, Xiaohong Liu, Xiaohua Huang, Omar D Lopez, John Easter

Drug Metab Dispos· June 2016

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Synthesis of isotopically labeled daclatasvir for use in human clinical studies.
John A Easter, Richard C Burrell, Samuel J Bonacorsi

J Labelled Comp Radiopharm· April 2016

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Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.
Hao Jiang, Hamza Kandoussi, Jianing Zeng, Jian Wang, Roger Demers, John Easter

J Pharm Biomed Anal· March 2015

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Challenges in accurate quantitation of lysophosphatidic acids in human biofluids.
Joelle M Onorato, Petia Shipkova, Anne Minnich, Anne-Françoise Aubry, John Easter

J Lipid Res· August 2014

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Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease.
Richard C Burrell, John A Easter, Michael P Cassidy, Kevin W Gillman, Richard E Olson

J Labelled Comp Radiopharm· August 2014

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An alternative and robust synthesis of [(13) C4 ]Baraclude® (entecavir).
John A Easter, Richard C Burrell, Samuel J Bonacorsi

J Labelled Comp Radiopharm· October 2013

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Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.
Hao Jiang, Jianing Zeng, Wenying Li, Marc Bifano, Huidong Gu, John Easter

Anal Chem· November 2012

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Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.
Huidong Gu, Jian Wang, Anne-Françoise Aubry, Hao Jiang, Jianing Zeng, John Easter

Anal Chem· June 2012

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Application of in-line liquid chromatography-accurate radioisotope counting-mass spectrometry (LC-ARC-MS) to evaluate metabolic profile of [3H]-mefenamic acid in rat plasma.
Wing Lam, Cho-Ming Loi, James Atherton, Wayne Stolle, John Easter

Drug Metab Lett· August 2007

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Assessment of radioactive residues arising from radiolabel instability in a multiple dose tissue distribution study in rats.
John Gregory Slatter, James Peter Sams, John Alan Easter, Gwendolyn Deane Fate, Koji Chiba

Biol Pharm Bull· May 2003

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