Publications by authors named "Huidong Gu"

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MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
Dong Cheng, Bradley A Zinker, Yi Luo, Petia Shipkova, Claudia H De Oliveira, Huidong Gu

Cell Metab· November 2022

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Biomarker Assay Validation by Mass Spectrometry.
Carmen Fernández-Metzler, Brad Ackermann, Fabio Garofolo, Mark E Arnold, Binodh DeSilva, Huidong Gu

AAPS J· May 2022

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Antipeptide Immunocapture with In-Sample Calibration Curve Strategy for Sensitive and Robust LC-MS/MS Bioanalysis of Clinical Protein Biomarkers in Formalin-Fixed Paraffin-Embedded Tumor Tissues.
Naiyu Zheng, Kristin Taylor, Huidong Gu, Rasa Santockyte, Xi-Tao Wang

Anal Chem· November 2020

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Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon-γ-Induced Protein 10, BMS-986184, in Healthy Participants to Guide Therapeutic Dosing.
Weiguo Cai, Tarek A Leil, Leonid Gibiansky, Murli Krishna, Hongwei Zhang, Huidong Gu

Clin Pharmacol Drug Dev· August 2020

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Fit-for-purpose protein biomarker assay validation strategies using hybrid immunocapture-liquid chromatography-tandem-mass spectrometry platform: Quantitative analysis of total soluble cluster of differentiation 73.
Yue Zhao, Huidong Gu, Jennifer Postelnek, Marissa DeMichele, Long Yuan

Anal Chim Acta· August 2020

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Application of in-sample calibration curve methodology for regulated bioanalysis: Critical considerations in method development, validation and sample analysis.
Long Yuan, Huidong Gu, Jianing Zeng, Renuka C Pillutla, Qin C Ji

J Pharm Biomed Anal· January 2020

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Eliminating Preparation of Multisample External Calibration Curves and Dilution of Study Samples Using the Multiple Isotopologue Reaction Monitoring (MIRM) Technique in Quantitative LC-MS/MS Bioanalysis.
Huidong Gu, Yue Zhao, Marissa DeMichele, Naiyu Zheng, Yan J Zhang

Anal Chem· July 2019

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Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS.
Naiyu Zheng, Ian M Catlett, Kristin Taylor, Huidong Gu, Mark A Pattoli

Anal Chem· July 2019

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In-Sample Calibration Curve Using Multiple Isotopologue Reaction Monitoring of a Stable Isotopically Labeled Analyte for Instant LC-MS/MS Bioanalysis and Quantitative Proteomics.
Huidong Gu, Yue Zhao, Marissa DeMichele, Naiyu Zheng, Yan J Zhang

Anal Chem· February 2019

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Critical considerations for immunocapture enrichment LC-MS bioanalysis of protein therapeutics and biomarkers.
Yue Zhao, Huidong Gu, Naiyu Zheng, Jianing Zeng

Bioanalysis· July 2018

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Opportunities and challenges for hybrid immunoaffinity LC-MS approach for quantitative analysis of protein biomarkers.
Yue Zhao, Huidong Gu, Jianing Zeng

Future Sci OA· March 2018

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Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker.
Hongwei Zhang, Huidong Gu, Petia Shipkova, Eugene Ciccimaro, Huadong Sun

Bioanalysis· October 2017

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Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug.
Ajit S Narang, Anand Balakrishnan, John Morrison, Jinjiang Li, Jennifer Wang, Huidong Gu

Eur J Pharm Biopharm· August 2017

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Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays.
Jian Wang, Huidong Gu, Ang Liu, Alexander Kozhich, Vangipuram Rangan

Bioanalysis· July 2016

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An integrated multiplatform bioanalytical strategy for antibody-drug conjugates: a novel case study.
Heather Myler, Vangipuram S Rangan, Jian Wang, Alexander Kozhich, Jennifer A Cummings, Huidong Gu

Bioanalysis· April 2016

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Quantitative bioanalysis of antibody-conjugated payload in monkey plasma using a hybrid immuno-capture LC-MS/MS approach: Assay development, validation, and a case study.
Ang Liu, Alexander Kozhich, David Passmore, Huidong Gu, Richard Wong

J Chromatogr B Analyt Technol Biomed Life Sci· October 2015

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Challenges and solutions in the bioanalysis of BMS-986094 and its metabolites including a highly polar, active nucleoside triphosphate in plasma and tissues using LC-MS/MS.
Ang Liu, John Lute, Huidong Gu, Bonnie Wang, Kevin J Trouba

J Chromatogr B Analyt Technol Biomed Life Sci· September 2015

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Selecting the correct weighting factors for linear and quadratic calibration curves with least-squares regression algorithm in bioanalytical LC-MS/MS assays and impacts of using incorrect weighting factors on curve stability, data quality, and assay performance.
Huidong Gu, Guowen Liu, Jian Wang, Anne-Françoise Aubry, Mark E Arnold

Anal Chem· September 2014

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Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease.
Amy Easton, Sethu Sankaranarayanan, An Tanghe, Dick Terwel, Alan X Lin, Huidong Gu

Psychopharmacology (Berl)· November 2013

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Development of a validated liquid chromatography tandem mass spectrometry assay for a PEGylated adnectin in cynomolgus monkey plasma using protein precipitation and trypsin digestion.
Michelle L Dawes, Huidong Gu, Jian Wang, Alan E Schuster, Jonathan Haulenbeek

J Chromatogr B Analyt Technol Biomed Life Sci· September 2013

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A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat.
Gary Tong, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Huidong Gu

Br J Clin Pharmacol· January 2013

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Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men.
Gary Tong, Lorna Castaneda, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Huidong Gu

Clin Drug Investig· November 2012

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Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.
Hao Jiang, Jianing Zeng, Wenying Li, Marc Bifano, Huidong Gu

Anal Chem· November 2012

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A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects.
Randy Dockens, Jun-Sheng Wang, Lorna Castaneda, Oleksandr Sverdlov, Shu-Pang Huang, Huidong Gu

Clin Pharmacokinet· October 2012

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Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.
Huidong Gu, Jian Wang, Anne-Françoise Aubry, Hao Jiang, Jianing Zeng

Anal Chem· June 2012

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