Publications by authors named "Omar D Lopez"

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Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems-based Resource.
Joel Morris, Mark W Kunkel, Stephen L White, Donn G Wishka, Omar D Lopez

Mol Cancer Ther· November 2023

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The development of β-selective glycosylation reactions with benzyl substituted 2-deoxy-1,4-dithio-D--pentofuranosides: enabling practical multi-gram syntheses of 4'-Thio-2'-deoxycytidine (T-dCyd) and 5-aza-4'-thio-2'-deoxycytidine (aza-T-dCyd) to support clinical development.
Donn G Wishka, Omar D Lopez, Vladimir F Rudchenko, Guangfei Huang, Robert Bahde

Nucleosides Nucleotides Nucleic Acids· June 2021

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F-aza-T-dCyd (NSC801845), a Novel Cytidine Analog, in Comparative Cell Culture and Xenograft Studies with the Clinical Candidates T-dCyd, F-T-dCyd, and Aza-T-dCyd.
Joel Morris, Donn G Wishka, Omar D Lopez, Vladimir Rudchenko, Guangfei Huang

Mol Cancer Ther· April 2021

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Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.
Arvind Mathur, Bei Wang, Daniel Smith, Jianqing Li, Joseph Pawluczyk, Omar D Lopez

J Org Chem· October 2017

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Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Wenying Li, Weiping Zhao, Xiaohong Liu, Xiaohua Huang, Omar D Lopez

Drug Metab Dispos· June 2016

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HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.
Denis R St Laurent, Michael H Serrano-Wu, Makonen Belema, Min Ding, Hua Fang, Omar D Lopez

J Med Chem· March 2014

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Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.
Makonen Belema, Van N Nguyen, Jeffrey L Romine, Denis R St Laurent, Omar D Lopez

J Med Chem· March 2014

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Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
Makonen Belema, Van N Nguyen, Carol Bachand, Dan H Deon, Jason T Goodrich, Omar D Lopez

J Med Chem· March 2014

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Discovery and development of hepatitis C virus NS5A replication complex inhibitors.
Makonen Belema, Omar D Lopez, John A Bender, Jeffrey L Romine, Denis R St Laurent

J Med Chem· March 2014

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HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.
Makonen Belema, Van N Nguyen, Denis R St Laurent, Omar D Lopez, Yuping Qiu

Bioorg Med Chem Lett· August 2013

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HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.
Omar D Lopez, Van N Nguyen, Denis R St Laurent, Makonen Belema, Michael H Serrano-Wu

Bioorg Med Chem Lett· February 2013

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HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.
Denis R St Laurent, Makonen Belema, Min Gao, Jason Goodrich, Ramesh Kakarla, Omar D Lopez

Bioorg Med Chem Lett· October 2012

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