Publications by authors named "Christopher Carreras"

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A platform technology for ultra-long acting intratumoral therapy.
Jeff Henise, John A Hangasky, Deborah Charych, Christopher W Carreras, Gary W Ashley

Sci Rep· June 2024

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Long-Acting Poly(ADP-ribose) Polymerase Inhibitor Prodrug for Humans.
Christopher W Carreras, Shaun D Fontaine, Ralph R Reid, Gary W Ashley, Daniel V Santi

Bioconjug Chem· April 2024

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A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors.
Shaun D Fontaine, Christopher W Carreras, Ralph R Reid, Gary W Ashley, Daniel V Santi

Cancer Res Commun· May 2023

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A long-acting C-natriuretic peptide for achondroplasia.
Eric L Schneider, Christopher W Carreras, Ralph Reid, Gary W Ashley, Daniel V Santi

Proc Natl Acad Sci U S A· July 2022

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Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na/H Exchanger Isoform 3.
Jeffrey W Jacobs, Michael R Leadbetter, Noah Bell, Samantha Koo-McCoy, Christopher W Carreras

ACS Med Chem Lett· July 2022

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Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.
Patricia D Finn, David Rodriguez, Jill Kohler, Zhengfeng Jiang, Sindy Wan, Christopher W Carreras

Am J Physiol Gastrointest Liver Physiol· March 2019

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Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).
Tao Chen, Nicholas William Reich, Noah Bell, Patricia D Finn, David Rodriguez, Christopher W Carreras

J Med Chem· September 2018

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Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD.
Eric D Labonté, Christopher W Carreras, Michael R Leadbetter, Kenji Kozuka, Jill Kohler

J Am Soc Nephrol· May 2015

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Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans.
Andrew G Spencer, Eric D Labonte, David P Rosenbaum, Craig F Plato, Christopher W Carreras

Sci Transl Med· March 2014

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The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series.
Yaoquan Liu, Christopher W Carreras, Mark Claypool, David C Myles, Simon J Shaw

Bioorg Med Chem Lett· June 2011

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9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety.
Yaoquan Liu, Yong Li, David C Myles, Mark Claypool, Christopher W Carreras

Bioorg Med Chem· November 2010

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9-Dihydroerythromycins as non-antibiotic motilin receptor agonists.
Yaoquan Liu, Yong Li, Yue Chen, Hao Zheng, Mark Claypool, Christopher W Carreras

Bioorg Med Chem Lett· October 2010

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Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety.
Simon J Shaw, Yue Chen, Hao Zheng, Hong Fu, Mark A Burlingame, Christopher W Carreras

J Med Chem· November 2009

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Potent cytotoxic C-11 modified geldanamycin analogues.
Zong-Qiang Tian, Zhan Wang, Karen S MacMillan, Yiqing Zhou, Christopher W Carreras

J Med Chem· May 2009

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Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
Hugo G Menzella, Thomas-Toan Tran, John R Carney, Janice Lau-Wee, Jorge Galazzo, Christopher Carreras

J Med Chem· March 2009

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Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.
Zong-Qiang Tian, Yaoquan Liu, Dan Zhang, Zhan Wang, Steven D Dong, Christopher W Carreras

Bioorg Med Chem· October 2004

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Filter binding assay for the geldanamycin-heat shock protein 90 interaction.
Christopher W Carreras, Andreas Schirmer, Ziyang Zhong, Daniel V Santi

Anal Biochem· June 2003

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Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins.
Christopher Carreras, Scott Frykman, Sally Ou, Lawrence Cadapan, Stefan Zavala

J Biotechnol· January 2002

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Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay.
Christopher W Carreras, Michael A Siani, Daniel V Santi, Susan B Dillon

Anal Biochem· January 2002

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