Publications by authors named "Christopher D Bahl"

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Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa.
Susu He, Noor M Taher, Adam R Simard, Kelli L Hvorecny, Michael J Ragusa, Christopher D Bahl

Nucleic Acids Res· November 2024

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Complete combinatorial mutational enumeration of a protein functional site enables sequence-landscape mapping and identifies highly-mutated variants that retain activity.
Mireia Solà Colom, Jelena Vučinić, Jared Adolf-Bryfogle, James W Bowman, Sébastien Verel, Christopher D Bahl

Protein Sci· August 2024

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Simultaneous enhancement of multiple functional properties using evolution-informed protein design.
Benjamin Fram, Yang Su, Ian Truebridge, Adam J Riesselman, John B Ingraham, Christopher D Bahl

Nat Commun· June 2024

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Growing Glycans in Rosetta: Accurate de novo glycan modeling, density fitting, and rational sequon design.
Jared Adolf-Bryfogle, Jason W Labonte, John C Kraft, Maxim Shapovalov, Sebastian Raemisch, Christopher D Bahl

PLoS Comput Biol· June 2024

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Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in .
Susu He, Noor M Taher, Kelli L Hvorecny, Michael J Ragusa, Christopher D Bahl

bioRxiv· January 2024

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Complete Combinatorial Mutational Enumeration of a protein functional site enables sequence-landscape mapping and identifies highly-mutated variants that retain activity.
Mireia Solà Colom, Jelena Vucinic, Jared Adolf-Bryfogle, James W Bowman, Sébastien Verel, Christopher D Bahl

Res Sq· September 2023

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Simultaneous enhancement of multiple functional properties using evolution-informed protein design.
Benjamin Fram, Ian Truebridge, Yang Su, Adam J Riesselman, John B Ingraham, Christopher D Bahl

bioRxiv· May 2023

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IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes.
Jose L Garrido, Matías A Medina, Felipe Bravo, Sarah McGee, Francisco Fuentes-Villalobos, Christopher D Bahl

Cell Rep· May 2022

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Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor.
Sibel Uzunçayır, Arturo Vera-Rodriguez, Paulina Regenthal, Hannah Åbacka, Cecilia Emanuelsson, Christopher D Bahl

FEBS Lett· April 2022

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Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks.
Julia Koehler Leman, Sergey Lyskov, Steven M Lewis, Jared Adolf-Bryfogle, Rebecca F Alford, Christopher D Bahl

Nat Commun· November 2021

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Toward complete rational control over protein structure and function through computational design.
Jared Adolf-Bryfogle, Frank D Teets, Christopher D Bahl

Curr Opin Struct Biol· February 2021

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Breakthroughs in computational design methods open up new frontiers for de novo protein engineering.
Ben A Meinen, Christopher D Bahl

Protein Eng Des Sel· February 2021

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Biochemical and structural characterization of two cif-like epoxide hydrolases from .
Noor M Taher, Kelli L Hvorecny, Cassandra M Burke, Morgan S A Gilman, Gary E Heussler, Christopher D Bahl

Curr Res Struct Biol· February 2021

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Structural characterization and computational analysis of PDZ domains in Monosiga brevicollis.
Melody Gao, Iain G P Mackley, Samaneh Mesbahi-Vasey, Haley A Bamonte, Sarah A Struyvenberg, Christopher D Bahl

Protein Sci· November 2020

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Integration of the Rosetta suite with the python software stack via reproducible packaging and core programming interfaces for distributed simulation.
Alexander S Ford, Brian D Weitzner, Christopher D Bahl

Protein Sci· January 2020

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Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides.
Garry W Buchko, Surya V S R K Pulavarti, Victor Ovchinnikov, Elizabeth A Shaw, Stephen A Rettie, Christopher D Bahl

Protein Sci· September 2018

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Discovery and engineering of enhanced SUMO protease enzymes.
Yue-Ting K Lau, Vladimir Baytshtok, Tessa A Howard, Brooke M Fiala, JayLee M Johnson, Christopher D Bahl

J Biol Chem· August 2018

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Screening, large-scale production and structure-based classification of cystine-dense peptides.
Colin E Correnti, Mesfin M Gewe, Christopher Mehlin, Ashok D Bandaranayake, William A Johnsen, Christopher D Bahl

Nat Struct Mol Biol· March 2018

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An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
Kelli L Hvorecny, Emily Dolben, Sophie Moreau-Marquis, Thomas H Hampton, Tamer B Shabaneh, Christopher D Bahl

Am J Physiol Lung Cell Mol Physiol· January 2018

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Massively parallel de novo protein design for targeted therapeutics.
Aaron Chevalier, Daniel-Adriano Silva, Gabriel J Rocklin, Derrick R Hicks, Renan Vergara, Christopher D Bahl

Nature· October 2017

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Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Kelli L Hvorecny, Christopher D Bahl, Seiya Kitamura, Kin Sing Stephen Lee, Bruce D Hammock

Structure· May 2017

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The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis.
Christopher D Bahl, Jessica D St Laurent, R Siva Ganesa Karthikeyan, J Lakshmi Priya, Lalitha Prajna

Cornea· March 2017

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Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
Becca A Flitter, Kelli L Hvorecny, Emiko Ono, Taylor Eddens, Jun Yang, Christopher D Bahl

Proc Natl Acad Sci U S A· January 2017

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Accurate de novo design of hyperstable constrained peptides.
Gaurav Bhardwaj, Vikram Khipple Mulligan, Christopher D Bahl, Jason M Gilmore, Peta J Harvey

Nature· October 2016

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Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.
Christopher D Bahl, Kelli L Hvorecny, Christophe Morisseau, Scott A Gerber, Dean R Madden

Biochemistry· February 2016

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