Publications by authors named "Christopher Douse"

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Retroviral insertions contributed to the divergence of human and chimpanzee brains.
Patricia Gerdes, Ofelia Karlsson, Raquel Garza, Diahann A M Atacho, PingHsun Hsieh, Christopher H Douse

bioRxiv· December 2025

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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development.
Anita Adami, Raquel Garza, Patricia Gerdes, Pia A Johansson, Fereshteh Dorazehi, Christopher H Douse

Cell Genom· October 2025

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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation.
Magdalena Madej, Phuong Cao Thi Ngoc, Sowndarya Muthukumar, Anna Konturek-Cieśla, Silvia Tucciarone, Christopher Douse

Cell Rep· June 2025

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Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease.
Vivien Horváth, Raquel Garza, Marie E Jönsson, Pia A Johansson, Anita Adami, Christopher H Douse

Nat Struct Mol Biol· October 2024

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DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor.
Ninoslav Pandiloski, Vivien Horváth, Ofelia Karlsson, Symela Koutounidou, Fereshteh Dorazehi, Christopher H Douse

Nat Commun· August 2024

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The annotation of has been concealed by its protein-coding pseudogene .
Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, Christopher H Douse

Sci Adv· June 2024

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Crystal structure and biochemical activity of the macrodomain from rubella virus p150.
Guido A Stoll, Nikos Nikolopoulos, Haoming Zhai, Liao Zhang, Christopher H Douse

J Virol· February 2024

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LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification.
Raquel Garza, Diahann A M Atacho, Anita Adami, Patricia Gerdes, Meghna Vinod, Christopher H Douse

Sci Adv· November 2023

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The DUF3715 domain has a conserved role in RNA-directed transposon silencing.
Theresa Schöpp, Daniil M Prigozhin, Christopher Douse, Keisuke Kaji, Atlanta G Cook

RNA· October 2023

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Structure and functional mapping of the KRAB-KAP1 repressor complex.
Guido A Stoll, Ninoslav Pandiloski, Christopher H Douse, Yorgo Modis

EMBO J· December 2022

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A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development.
Pia A Johansson, Per Ludvik Brattås, Christopher H Douse, PingHsun Hsieh, Anita Adami

Cell Stem Cell· January 2022

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Periphilin self-association underpins epigenetic silencing by the HUSH complex.
Daniil M Prigozhin, Christopher H Douse, Laura E Farleigh, Anna Albecka, Iva A Tchasovnikarova

Nucleic Acids Res· October 2020

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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Christopher H Douse, Iva A Tchasovnikarova, Richard T Timms, Anna V Protasio, Marta Seczynska

Nat Commun· October 2020

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Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Christopher H Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A Tchasovnikarova

Nat Commun· February 2018

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Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
Iva A Tchasovnikarova, Richard T Timms, Christopher H Douse, Rhys C Roberts, Gordon Dougan

Nat Genet· July 2017

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Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation.
James A Garnett, Daniela Muhl, Christopher H Douse, Kailyn Hui, Andreas Busch

Protein Sci· May 2015

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The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.
Noor A Yusuf, Judith L Green, Richard J Wall, Ellen Knuepfer, Robert W Moon, Christopher H Douse

J Biol Chem· May 2015

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Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex.
Christopher H Douse, Nina Vrielink, Zhang Wenlin, Ernesto Cota, Edward W Tate

ChemMedChem· January 2015

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Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction.
Christopher H Douse, Sabrina J Maas, Jemima C Thomas, James A Garnett, Yunyun Sun

ACS Chem Biol· October 2014

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Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA.
Christopher H Douse, Judith L Green, Paula S Salgado, Peter J Simpson, Jemima C Thomas

J Biol Chem· October 2012

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