Publications by authors named "Christopher Dowson"

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Transcriptomic and enzymological evidence for plastid peptidoglycan synthesis in the gymnosperm Picea abies.
Yayoi Sugita, Amanda J Dowson, Ichiro Kajisa, Katsuaki Takechi, Yilan E, Christopher G Dowson

Plant J· December 2025

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Discovery and chemical optimisation of a potent, Bi-cyclic antimicrobial inhibitor of Escherichia coli PBP3.
Catherine E Rowland, Hector Newman, Tazmin T Martin, Rachel Dods, Nikolaos Bournakas, Christopher G Dowson

Commun Biol· May 2025

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Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case-Control Study.
Ahmed Khudhur, Christopher Dowson, Susan M Bissett, Rachel van de Merwe, John J Taylor

Int J Dent Hyg· November 2024

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Retroperitoneal Extrusion of a Staghorn Calculus With a Nephrocutaneous Fistula Following a Percutaneous Nephrostomy: A Case Report and Literature Review.
Mohamed S Mohsin, Nader F Gaballa, Shankar Chandrasekharan, Christopher J Dowson

Cureus· June 2024

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A conserved zinc-binding site in PBP2 required for elongasome-directed bacterial cell shape.
Carmina Micelli, Yunfei Dai, Nicole Raustad, Ralph R Isberg, Christopher G Dowson

Proc Natl Acad Sci U S A· February 2023

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Genomic Assembly of Clinical Candida glabrata (Nakaseomyces glabrata) Isolates Reveals within-Species Structural Plasticity and Association with Antifungal Susceptibility.
Irene Stefanini, Emily Stoakes, Houdini H T Wu, Li Xu-McCrae, Abid Hussain, Christopher G Dowson

Microbiol Spectr· December 2022

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Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram-negative bacteria.
Amanda J Dowson, Adrian J Lloyd, Andrew C Cuming, David I Roper, Lorenzo Frigerio, Christopher G Dowson

Plant Physiol· August 2022

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Synthetic Sansanmycin Analogues as Potent Translocase I Inhibitors.
Wendy Tran, Ali S Kusay, Paige M E Hawkins, Chen-Yi Cheung, Gayathri Nagalingam, Christopher G Dowson

J Med Chem· December 2021

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The effect of high-speed dental handpiece coolant delivery and design on aerosol and droplet production.
James R Allison, David C Edwards, Charlotte Bowes, Kimberley Pickering, Christopher Dowson

J Dent· September 2021

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High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
Hector Newman, Alen Krajnc, Dom Bellini, Charles J Eyermann, Grant A Boyle, Christopher G Dowson

J Med Chem· August 2021

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Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane.
Anna York, Adrian J Lloyd, Charo I Del Genio, Jonathan Shearer, Karen J Hinxman, Christopher G Dowson

Structure· July 2021

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There is no market for new antibiotics: this allows an open approach to research and development.
Dana M Klug, Fahima I M Idiris, Mark A T Blaskovich, Frank von Delft, Christopher G Dowson

Wellcome Open Res· June 2021

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A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in .
Surya D Aggarwal, Adrian J Lloyd, Saigopalakrishna S Yerneni, Ana Rita Narciso, Jennifer Shepherd, Christopher G Dowson

Proc Natl Acad Sci U S A· April 2021

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Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Christopher G Dowson

Chem Sci· May 2020

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Correction: Metal complexes as a promising source for new antibiotics.
Angelo Frei, Johannes Zuegg, Alysha G Elliott, Murray Baker, Stefan Braese, Christopher G Dowson

Chem Sci· April 2020

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Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin.
Laura C Jacques, Stavros Panagiotou, Murielle Baltazar, Madikay Senghore, Shadia Khandaker, Christopher G Dowson

Nat Commun· April 2020

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Investigating Bacteriophages Targeting the Opportunistic Pathogen .
Kathryn M Styles, Rapee Thummeepak, Udomluk Leungtongkam, Sophie E Smith, Gabrielle S Christie, Christopher G Dowson

Antibiotics (Basel)· April 2020

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Substrate and Stereochemical Control of Peptidoglycan Cross-Linking by Transpeptidation by PBP1B.
Anita C Catherwood, Adrian J Lloyd, Julie A Tod, Smita Chauhan, Susan E Slade, Christopher G Dowson

J Am Chem Soc· March 2020

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Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase.
Ricky Cain, Ramya Salimraj, Avinash S Punekar, Dom Bellini, Colin W G Fishwick, Christopher G Dowson

J Med Chem· November 2019

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Evaluation of a Library of FDA-Approved Drugs for Their Ability To Potentiate Antibiotics against Multidrug-Resistant Gram-Negative Pathogens.
Charlotte K Hind, Christopher G Dowson, J Mark Sutton, Thomas Jackson, Melanie Clifford

Antimicrob Agents Chemother· August 2019

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Profiling interactions of vaborbactam with metallo-β-lactamases.
Gareth W Langley, Ricky Cain, Jonathan M Tyrrell, Philip Hinchliffe, Karina Calvopiña, Christopher G Dowson

Bioorg Med Chem Lett· August 2019

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The Molecular Basis of Antibiotic Action and Resistance.
Anthony Maxwell, Christopher G Dowson, James Spencer

J Mol Biol· August 2019

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Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of β-Lactam Target-Mediated Resistance.
Dom Bellini, Lizbé Koekemoer, Hector Newman, Christopher G Dowson

J Mol Biol· August 2019

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Detection of "Hidden" Antimicrobial Drug Resistance.
Qingfeng Hu, Yan Yu, Dongshi Gu, Li Xie, Xingrou Chen, Christopher Dowson

ACS Infect Dis· July 2019

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Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.
Ahmad Massarweh, Michael Bosco, Isabelle Chantret, Thibaut Léger, Layla Jamal, Christopher G Dowson

Molecules· June 2019

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