Publications by authors named "Christopher F Stratton"

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Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Guozhang Xu, Zhijie Liu, Xinkang Wang, Tianbao Lu, Renee L DesJarlais, Christopher F Stratton

J Med Chem· August 2022

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Niraparib Shows Superior Tissue Distribution and Efficacy in a Prostate Cancer Bone Metastasis Model Compared with Other PARP Inhibitors.
Linda A Snyder, Rajendra Damle, Shefali Patel, Jared Bohrer, Anna Fiorella, Christopher F Stratton

Mol Cancer Ther· July 2022

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Binding Isotope Effects for Interrogating Enzyme-Substrate Interactions.
Christopher F Stratton, Myles B Poulin, Vern L Schramm

Methods Enzymol· May 2018

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Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase.
Christopher F Stratton, Myles B Poulin, Quan Du, Vern L Schramm

ACS Chem Biol· February 2017

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Transition State Structure and Inhibition of Rv0091, a 5'-Deoxyadenosine/5'-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.
Hilda A Namanja-Magliano, Christopher F Stratton, Vern L Schramm

ACS Chem Biol· June 2016

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Transition State Structure of RNA Depurination by Saporin L3.
Hongling Yuan, Christopher F Stratton, Vern L Schramm

ACS Chem Biol· May 2016

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Cheminformatic comparison of approved drugs from natural product versus synthetic origins.
Christopher F Stratton, David J Newman, Derek S Tan

Bioorg Med Chem Lett· November 2015

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Binding Isotope Effects for para-Aminobenzoic Acid with Dihydropteroate Synthase from Staphylococcus aureus and Plasmodium falciparum.
Christopher F Stratton, Hilda A Namanja-Magliano, Scott A Cameron, Vern L Schramm

ACS Chem Biol· October 2015

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Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries.
Todd A Wenderski, Christopher F Stratton, Renato A Bauer, Felix Kopp, Derek S Tan

Methods Mol Biol· September 2015

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Immucillin-H, a purine nucleoside phosphorylase transition state analog, causes non-lethal attenuation of growth in Staphylococcus aureus.
Christopher F Stratton, Vern L Schramm

Bioinformation· February 2013

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A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
Felix Kopp, Christopher F Stratton, Lakshmi B Akella, Derek S Tan

Nat Chem Biol· March 2012

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Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.
Hua Xu, Todd J Sullivan, Jun-ichiro Sekiguchi, Teruo Kirikae, Iwao Ojima, Christopher F Stratton

Biochemistry· April 2008

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Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis.
Alasdair F Bell, Christopher F Stratton, Xujie Zhang, Polina Novichenok, Andrew A Jaye

J Am Chem Soc· May 2007

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Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
Salma Rafi, Polina Novichenok, Subramaniapillai Kolappan, Christopher F Stratton, Richa Rawat

J Biol Chem· December 2006

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High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis.
Todd J Sullivan, James J Truglio, Melissa E Boyne, Polina Novichenok, Xujie Zhang, Christopher F Stratton

ACS Chem Biol· February 2006

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