Publications by authors named "Christopher Francklyn"

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The catechol moiety of obafluorin is essential for antibacterial activity.
Sibyl F D Batey, Melissa J Davie, Edward S Hems, Jonathon D Liston, Thomas A Scott, Christopher S Francklyn

RSC Chem Biol· November 2023

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Neuropathy-associated histidyl-tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish.
Patrick Mullen, Jamie A Abbott, Theresa Wellman, Mahafuza Aktar, Christian Fjeld, Christopher S Francklyn

FEBS J· January 2021

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De Novo and Bi-allelic Pathogenic Variants in NARS1 Cause Neurodevelopmental Delay Due to Toxic Gain-of-Function and Partial Loss-of-Function Effects.
Andreea Manole, Stephanie Efthymiou, Emer O'Connor, Marisa I Mendes, Matthew Jennings, Christopher S Francklyn

Am J Hum Genet· August 2020

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Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome.
Daniele Galatolo, Molly E Kuo, Patrick Mullen, Rebecca Meyer-Schuman, Stefano Doccini, Christopher Francklyn

Hum Mutat· July 2020

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Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic.
Thomas A Scott, Sibyl F D Batey, Patrick Wiencek, Govind Chandra, Silke Alt, Christopher S Francklyn

ACS Chem Biol· December 2019

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Peripheral neuropathy and cognitive impairment associated with a novel monoallelic variant.
Béryl Royer-Bertrand, Pinelopi Tsouni, Patrick Mullen, Belinda Campos Xavier, Lauréane Mittaz Crettol, Christopher Francklyn

Ann Clin Transl Neurol· June 2019

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Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.
Christopher S Francklyn, Patrick Mullen

J Biol Chem· April 2019

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Knock-Down of Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells .
Ashley Waldron, Claire Wilcox, Christopher Francklyn, Alicia Ebert

Front Cell Dev Biol· April 2019

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Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish.
Aleksandra Siekierska, Hannah Stamberger, Tine Deconinck, Stephanie N Oprescu, Michèle Partoens, Christopher Francklyn

Nat Commun· February 2019

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11th IUBMB Focused Meeting on the Aminoacyl-tRNA Synthetases: Sailing a New Sea of Complex Functions in Human Biology and Disease.
Christopher Francklyn, Herve Roy, Rebecca Alexander

Biomolecules· May 2018

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Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy.
Jamie A Abbott, Rebecca Meyer-Schuman, Vincenzo Lupo, Shawna Feely, Inès Mademan, Christopher Francklyn

Hum Mutat· March 2018

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Correction: A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.
Ashley L Waldron, Sara Helms Cahan, Christopher S Francklyn, Alicia M Ebert

PLoS One· January 2018

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A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases.
Ashley L Waldron, Sara Helms Cahan, Christopher S Francklyn, Alicia M Ebert

PLoS One· October 2017

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The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.
Jamie A Abbott, Ethan Guth, Cindy Kim, Cathy Regan, Victoria M Siu, Christopher S Francklyn

Biochemistry· July 2017

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Characterization of aminoacyl-tRNA synthetase stability and substrate interaction by differential scanning fluorimetry.
Jamie A Abbott, Nathan M Livingston, Shawn B Egri, Ethan Guth, Christopher S Francklyn

Methods· January 2017

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Aminoacyl-tRNA synthetases.
Christopher Francklyn

Methods· January 2017

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Aminoacyl-Transfer RNA Synthetases: Connecting Nutrient Status to Angiogenesis Through the Unfolded Protein Response.
Karen M Lounsbury, Christopher S Francklyn

Arterioscler Thromb Vasc Biol· April 2016

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Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.
Adam C Mirando, Pengfei Fang, Tamara F Williams, Linda C Baldor, Alan K Howe, Christopher S Francklyn

Sci Rep· August 2015

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Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Pengfei Fang, Xue Yu, Seung Jae Jeong, Adam Mirando, Kaige Chen, Christopher S Francklyn

Nat Commun· March 2015

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Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.
Eva Maria Novoa, Noelia Camacho, Anna Tor, Barrie Wilkinson, Steven Moss, Christopher S Francklyn

Proc Natl Acad Sci U S A· December 2014

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Regulation of angiogenesis by aminoacyl-tRNA synthetases.
Adam C Mirando, Christopher S Francklyn, Karen M Lounsbury

Int J Mol Sci· December 2014

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Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer.
Theresa L Wellman, Midori Eckenstein, Cheung Wong, Mercedes Rincon, Takamaru Ashikaga, Christopher S Francklyn

BMC Cancer· August 2014

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Transfer RNA and human disease.
Jamie A Abbott, Christopher S Francklyn, Susan M Robey-Bond

Front Genet· June 2014

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Standardizing analysis of circulating microRNA: clinical and biological relevance.
Nicholas H Farina, Marie E Wood, Scott D Perrapato, Christopher S Francklyn, Gary S Stein

J Cell Biochem· May 2014

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Aminoacylating urzymes challenge the RNA world hypothesis.
Li Li, Christopher Francklyn, Charles W Carter

J Biol Chem· September 2013

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