Publications by authors named "Christopher Lipinski"

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Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial.
Suzana Margareth Lobo, Gaétan Plantefève, Girish Nair, Adilson Joaquim Cavalcante, Nara Franzin de Moraes, Christopher Lipinski

EClinicalMedicine· February 2024

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Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs.
Christopher A Lipinski, Andrew G Reaume

Front Pharmacol· August 2022

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Chloroquine Ingestion to Prevent SARS-CoV-2 Infection: A Report of Two Cases.
Jonathan Graff, Michelle Geyer Thompson, Zachary Berriochoa, Bryan Kuhn, Anne-Michelle Ruha, Christopher Lipinski

Clin Pract Cases Emerg Med· May 2021

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High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept.
Christopher A Lipinski, Andrew G Reaume

Bioorg Med Chem· May 2020

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Serum Lactate and Mortality in Emergency Department Patients with Cancer.
Steven A Maher, M'hamed Temkit, Matthew R Buras, Ryan Y McLemore, Rebecca K Butler, Christopher A Lipinski

West J Emerg Med· September 2018

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The rule of five should not impede anti-parasitic drug development.
James H McKerrow, Christopher A Lipinski

Int J Parasitol Drugs Drug Resist· August 2017

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Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions.
Christopher A Lipinski

Adv Drug Deliv Rev· June 2016

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Physician in Triage Versus Rotational Patient Assignment.
Stephen J Traub, Adam C Bartley, Vernon D Smith, Roshanak Didehban, Christopher A Lipinski

J Emerg Med· May 2016

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Badapple: promiscuity patterns from noisy evidence.
Jeremy J Yang, Oleg Ursu, Christopher A Lipinski, Larry A Sklar, Tudor I Oprea

J Cheminform· May 2016

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Emergency Department Rotational Patient Assignment.
Stephen J Traub, Christopher F Stewart, Roshanak Didehban, Adam C Bartley, Soroush Saghafian, Christopher A Lipinski

Ann Emerg Med· February 2016

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Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods.
Sean Ekins, Nadia K Litterman, Christopher A Lipinski, Barry A Bunin

Pharm Res· January 2016

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Emergency department rapid medical assessment: overall effect and mechanistic considerations.
Stephen J Traub, Joseph P Wood, James Kelley, David M Nestler, Yu-Hui Chang, Christopher A Lipinski

J Emerg Med· May 2015

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Parallel worlds of public and commercial bioactive chemistry data.
Christopher A Lipinski, Nadia K Litterman, Christopher Southan, Antony J Williams, Alex M Clark

J Med Chem· March 2015

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Small molecules with antiviral activity against the Ebola virus.
Nadia Litterman, Christopher Lipinski, Sean Ekins

F1000Res· February 2015

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Computational prediction and validation of an expert's evaluation of chemical probes.
Nadia K Litterman, Christopher A Lipinski, Barry A Bunin, Sean Ekins

J Chem Inf Model· October 2014

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Safety of epinephrine for anaphylaxis in the emergency setting.
Joseph P Wood, Stephen J Traub, Christopher Lipinski

World J Emerg Med· September 2014

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Flashback phenomenon and residual neurological deficits after the use of "bath salt" 3, 4- methylenedioxypyrovalerone.
Aaron R Mangold, Thomas P Bravo, Stephen J Traub, Steven A Maher, Christopher A Lipinski

World J Emerg Med· September 2014

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Emergency department physician telemedical triage.
Stephen J Traub, Rebecca Butler, Yu-Hui Chang, Christopher Lipinski

Telemed J E Health· November 2013

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The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.
Alexander R Ochman, Christopher A Lipinski, Jeffrey A Handler, Andrew G Reaume, Michael S Saporito

J Pharmacol Exp Ther· July 2012

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MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.
Michael S Saporito, Alexander R Ochman, Christopher A Lipinski, Jeffrey A Handler, Andrew G Reaume

J Pharmacol Exp Ther· July 2012

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Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis.
Sean Ekins, Takushi Kaneko, Christopher A Lipinski, Justin Bradford, Krishna Dole

Mol Biosyst· November 2010

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Olfactory and gustatory hallucinations presenting as partial status epilepticus because of glioblastoma multiforme.
Dan J Capampangan, Matthew T Hoerth, Joseph F Drazkowski, Christopher A Lipinski

Ann Emerg Med· October 2010

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The autophilic anti-CD20 antibody DXL625 displays enhanced potency due to lipid raft-dependent induction of apoptosis.
Marc G Bingaman, Gargi D Basu, Tiana C Golding, Samuel K Chong, Andrew J Lassen, Christopher A Lipinski

Anticancer Drugs· June 2010

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Targeting Pyk2 for therapeutic intervention.
Christopher A Lipinski, Joseph C Loftus

Expert Opin Ther Targets· January 2010

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Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2.
Nathalie Meurice, Lei Wang, Christopher A Lipinski, Zhongbo Yang, Christopher Hulme

J Med Chem· January 2010

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