Publications by authors named "Joseph C Loftus"

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Glioblastoma resistance to EGFR antibody-drug conjugate is driven by transcriptional reprogramming and TEK-induced EGFR suppression.
Mylan R Blomquist, Teresa M R Noviello, Christopher Sereduk, Dustin Grief, Francesca P Caruso, Joseph C Loftus

J Transl Med· October 2025

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EGFRvIII Confers Sensitivity to Saracatinib in a STAT5-Dependent Manner in Glioblastoma.
Mylan R Blomquist, Ryan Eghlimi, Angad Beniwal, Dustin Grief, David G Nascari, Joseph C Loftus

Int J Mol Sci· June 2024

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Leukemia-Associated Rho Guanine Nucleotide Exchange Factor and Ras Homolog Family Member C Play a Role in Glioblastoma Cell Invasion and Resistance.
Zonghui Ding, Zhiwan Dong, Yuping Yang, Shannon P Fortin Ensign, Hemragul Sabit, Joseph C Loftus

Am J Pathol· October 2020

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TROY signals through JAK1-STAT3 to promote glioblastoma cell migration and resistance.
Zonghui Ding, Jean M Kloss, Serdar Tuncali, Nhan L Tran, Joseph C Loftus

Neoplasia· September 2020

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Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells.
Bryan G Harder, Sen Peng, Christopher P Sereduk, Andrej M Sodoma, Gaspar J Kitange, Joseph C Loftus

Mol Med· November 2019

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PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival.
Zonghui Ding, Harshil Dhruv, Aneta Kwiatkowska-Piwowarczyk, Rosamaria Ruggieri, Jean Kloss, Joseph C Loftus

Neoplasia· October 2018

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Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma.
Bryan G Harder, Mylan R Blomquist, Junwen Wang, Anthony J Kim, Graeme F Woodworth, Joseph C Loftus

Front Oncol· October 2018

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EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival.
Alison Roos, Harshil D Dhruv, Sen Peng, Landon J Inge, Serdar Tuncali, Joseph C Loftus

Mol Cancer Res· July 2018

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A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion.
Zonghui Ding, Alison Roos, Jean Kloss, Harshil Dhruv, Sen Peng, Joseph C Loftus

Mol Cancer Res· February 2018

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Molecular and Microenvironmental Determinants of Glioma Stem-Like Cell Survival and Invasion.
Alison Roos, Zonghui Ding, Joseph C Loftus, Nhan L Tran

Front Oncol· June 2017

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Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells.
Alison Roos, Harshil D Dhruv, Ian T Mathews, Landon J Inge, Serdar Tuncali, Joseph C Loftus

Oncotarget· February 2017

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Radiogenomics to characterize regional genetic heterogeneity in glioblastoma.
Leland S Hu, Shuluo Ning, Jennifer M Eschbacher, Leslie C Baxter, Nathan Gaw, Joseph C Loftus

Neuro Oncol· January 2017

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SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.
Shannon P Fortin Ensign, Alison Roos, Ian T Mathews, Harshil D Dhruv, Serdar Tuncali, Joseph C Loftus

Mol Cancer Res· March 2016

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Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway.
Harshil D Dhruv, Alison Roos, Patrick J Tomboc, Serdar Tuncali, Ashley Chavez, Joseph C Loftus

J Neurooncol· February 2016

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Reciprocal activation of transcription factors underlies the dichotomy between proliferation and invasion of glioma cells.
Harshil D Dhruv, Wendy S McDonough Winslow, Brock Armstrong, Serdar Tuncali, Jenny Eschbacher, Joseph C Loftus

PLoS One· September 2014

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Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.
Yael Kusne, Eugenio A Carrera-Silva, Anthony S Perry, Elisabeth J Rushing, Edward K Mandell, Joseph C Loftus

Sci Signal· August 2014

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Differential expression of microRNAs as predictors of glioblastoma phenotypes.
Barrie S Bradley, Joseph C Loftus, Clinton J Mielke, Valentin Dinu

BMC Bioinformatics· January 2014

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Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis.
Harshil Dhruv, Joseph C Loftus, Pooja Narang, Joachim L Petit, Maureen Fameree

J Biol Chem· November 2013

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A Novel Interaction between Pyk2 and MAP4K4 Is Integrated with Glioma Cell Migration.
Joseph C Loftus, Zhongbo Yang, Jean Kloss, Harshil Dhruv, Nhan L Tran

J Signal Transduct· October 2013

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TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance.
Joseph C Loftus, Harshil Dhruv, Serdar Tuncali, Jean Kloss, Zhongbo Yang

Mol Cancer Res· August 2013

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The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2.
Shannon P Fortin Ensign, Ian T Mathews, Jennifer M Eschbacher, Joseph C Loftus, Marc H Symons

J Biol Chem· July 2013

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New insights into the functional consequences of ephrin A3 mutations in non-small cell lung cancer.
Timothy G Whitsett, Joseph C Loftus, Jeffrey A Winkles, Nhan L Tran

Transl Lung Cancer Res· February 2013

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miRNA expression profiling in migrating glioblastoma cells: regulation of cell migration and invasion by miR-23b via targeting of Pyk2.
Joseph C Loftus, Julianna T D Ross, Kimberly M Paquette, Vincent M Paulino, Sara Nasser

PLoS One· November 2012

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Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
Shannon P Fortin, Matthew J Ennis, Cassie A Schumacher, Cassandra R Zylstra-Diegel, Bart O Williams, Joseph C Loftus

Mol Cancer Res· July 2012

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Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion.
Timothy G Whitsett, Emily Cheng, Landon Inge, Kaushal Asrani, Nathan M Jameson, Joseph C Loftus

Am J Pathol· July 2012

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