Publications by authors named "Christopher Luckhurst"

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Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.
Tracy-Shi Zhang Fang, Yu Sun, Andrew C Pearce, Simona Eleuteri, Mark Kemp, Christopher A Luckhurst

Nat Commun· November 2023

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Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
Tammy Ladduwahetty, Matthew R Lee, Michel C Maillard, Roger Cachope, Daniel Todd, Christopher A Luckhurst

J Med Chem· July 2022

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Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.
Andrew J Stott, Michel C Maillard, Vahri Beaumont, David Allcock, Omar Aziz, Christopher A Luckhurst

ACS Med Chem Lett· March 2021

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Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Christopher A Luckhurst, Omar Aziz, Vahri Beaumont, Roland W Bürli, Perla Breccia

Bioorg Med Chem Lett· January 2019

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Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
Christopher A Luckhurst, Perla Breccia, Andrew J Stott, Omar Aziz, Helen L Birch

ACS Med Chem Lett· January 2016

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Cathepsin C inhibitors: property optimization and identification of a clinical candidate.
Mark Furber, Anna-Karin Tiden, Philip Gardiner, Antonio Mete, Rhonan Ford, Christopher Luckhurst

J Med Chem· March 2014

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Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
Roland W Bürli, Christopher A Luckhurst, Omar Aziz, Kim L Matthews, Dawn Yates

J Med Chem· December 2013

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Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part II: optimising in vivo clearance.
Mark Furber, Lilian Alcaraz, Christopher Luckhurst, Ash Bahl, Haydn Beaton

Bioorg Med Chem Lett· December 2012

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Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H₁ antagonists. Part I.
Mark Furber, Lilian Alcaraz, Christopher Luckhurst, Ash Bahl, Haydn Beaton

Bioorg Med Chem Lett· December 2012

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Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.
Ash Bahl, Patrick Barton, Keith Bowers, Moya V Caffrey, Rebecca Denton, Christopher A Luckhurst

Bioorg Med Chem Lett· November 2012

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The discovery of CCR3/H1 dual antagonists with reduced hERG risk.
Ash Bahl, Patrick Barton, Keith Bowers, Steven Brough, Richard Evans, Christopher A Luckhurst

Bioorg Med Chem Lett· November 2012

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Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists.
Christopher A Luckhurst, Marianne Ratcliffe, Linda Stein, Mark Furber, Sara Botterell

Bioorg Med Chem Lett· January 2011

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Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.
Christopher A Luckhurst, Linda A Stein, Mark Furber, Nicola Webb, Marianne J Ratcliffe

Bioorg Med Chem Lett· January 2011

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