Publications by authors named "Christopher N Toepfer"

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Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery.
Samuel T M Jones, Flair E Paradine Cullup, Sampath K Gollapudi, Elise G Melhedegaard, Violetta Steeples, Christopher N Toepfer

Nat Protoc· December 2025

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An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten.
Lisa Leinhos, Paul Robinson, Giulia Poloni, Sophie Broadway-Stringer, Julia Beglov, Christopher N Toepfer

Sci Rep· March 2025

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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy.
Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B Stöckl, Manuel Schmid, Christopher N Toepfer

Sci Rep· January 2025

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Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
Yuri Kim, Seong Won Kim, David Saul, Meraj Neyazi, Manuel Schmid, Christopher N Toepfer

J Clin Invest· December 2024

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Microscale droplet assembly enables biocompatible multifunctional modular iontronics.
Yujia Zhang, Cheryl M J Tan, Christopher N Toepfer, Xin Lu, Hagan Bayley

Science· November 2024

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Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling.
Jourdan K Ewoldt, Miranda C Wang, Micheal A McLellan, Paige E Cloonan, Anant Chopra, Christopher N Toepfer

Sci Adv· October 2024

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Targeted genetic therapies for inherited disorders that affect both cardiac and skeletal muscle.
Yiangos Psaras, Christopher N Toepfer

Exp Physiol· February 2024

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Comparing the effects of chemical Ca dyes and R-GECO on contractility and Ca transients in adult and human iPSC cardiomyocytes.
Paul Robinson, Alexander J Sparrow, Yiangos Psaras, Violetta Steeples, Jillian N Simon, Christopher N Toepfer

J Mol Cell Cardiol· July 2023

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Cardiomyocyte infection by promotes innate immune response and glycolysis activation.
Gabriela Venturini, Juliana M Alvim, Kallyandra Padilha, Christopher N Toepfer, Joshua M Gorham

Front Cell Infect Microbiol· February 2023

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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy.
Francesca Margara, Yiangos Psaras, Zhinuo Jenny Wang, Manuel Schmid, Ruben Doste, Christopher N Toepfer

Sci Rep· December 2022

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Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome.
Anna B Meier, Sarala Raj Murthi, Hilansi Rawat, Christopher N Toepfer, Gianluca Santamaria

iScience· January 2022

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Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization.
Kehan Zhang, Paige E Cloonan, Subramanian Sundaram, Feng Liu, Shoshana L Das, Christopher N Toepfer

Sci Adv· October 2021

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Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation.
Radhika Agarwal, Joao A Paulo, Christopher N Toepfer, Jourdan K Ewoldt, Subramanian Sundaram

Circ Res· September 2021

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CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes.
Yiangos Psaras, Francesca Margara, Marcelo Cicconet, Alexander J Sparrow, Giuliana G Repetti, Christopher N Toepfer

Circ Res· July 2021

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Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics.
Manuel Schmid, Christopher N Toepfer

Biol Open· February 2021

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Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in and That Are Common in Chinese Patients.
Chee Jian Pua, Nevin Tham, Calvin W L Chin, Roddy Walsh, Chiea Chuen Khor, Christopher N Toepfer

Circ Genom Precis Med· October 2020

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mutations in hiPSCs inform mechanisms for maldevelopment of the heart, pancreas, and diaphragm.
Arun Sharma, Lauren K Wasson, Jon Al Willcox, Sarah U Morton, Joshua M Gorham, Christopher N Toepfer

Elife· October 2020

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Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Christopher N Toepfer, Amanda C Garfinkel, Gabriela Venturini, Hiroko Wakimoto, Giuliana Repetti

Circulation· March 2020

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Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy.
Pablo Garcia-Pavia, Yuri Kim, Maria Alejandra Restrepo-Cordoba, Ida G Lunde, Hiroko Wakimoto, Christopher N Toepfer

Circulation· July 2019

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Novel Therapies for Prevention and Early Treatment of Cardiomyopathies.
Giuliana G Repetti, Christopher N Toepfer, Jonathan G Seidman, Christine E Seidman

Circ Res· May 2019

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SarcTrack.
Christopher N Toepfer, Arun Sharma, Marcelo Cicconet, Amanda C Garfinkel, Michael Mücke

Circ Res· April 2019

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Hypertrophic cardiomyopathy mutations in dysregulate myosin.
Christopher N Toepfer, Hiroko Wakimoto, Amanda C Garfinkel, Barbara McDonough, Dan Liao

Sci Transl Med· January 2019

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Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor.
Yuxuan Guo, Blake D Jardin, Pingzhu Zhou, Isha Sethi, Brynn N Akerberg, Christopher N Toepfer

Nat Commun· September 2018

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CRISPR/Cas9-Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells.
Arun Sharma, Christopher N Toepfer, Tarsha Ward, Lauren Wasson, Radhika Agarwal

Curr Protoc Hum Genet· January 2018

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Differentiation and Contractile Analysis of GFP-Sarcomere Reporter hiPSC-Cardiomyocytes.
Arun Sharma, Christopher N Toepfer, Manuel Schmid, Amanda C Garfinkel, Christine E Seidman

Curr Protoc Hum Genet· January 2018

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