Publications by authors named "Christopher Patten"

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Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787.
David J Hirst, Paul Bamborough, Niam Al-Mahdi, Davina C Angell, Heather A Barnett, Christopher Patten

J Med Chem· June 2024

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Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
Philip G Humphreys, Niall A Anderson, Paul Bamborough, Andrew Baxter, Chun-Wa Chung, Christopher Patten

J Med Chem· November 2022

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Estimated time of arrival and debiasing the time saving bias.
Gabriella Eriksson, Christopher J D Patten, Ola Svenson, Lars Eriksson

Ergonomics· December 2016

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New technologies for assessing UDP-glucuronosyltransferase (UGT) metabolism in drug discovery and development.
Christopher J Patten

Drug Discov Today Technol· July 2014

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Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.
Michael H Court, Fawziah E Almutairi, David J Greenblatt, Suwagmani Hazarika, Hongyan Sheng, Christopher J Patten

Antimicrob Agents Chemother· July 2014

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Effects of electronic billboards on driver distraction.
Tania Dukic, Christer Ahlstrom, Christopher Patten, Carmen Kettwich, Katja Kircher

Traffic Inj Prev· July 2013

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Driver distraction in an unusual environment: Effects of text-messaging in tunnels.
Christina M Rudin-Brown, Kristie L Young, Christopher Patten, Michael G Lenné, Ruggero Ceci

Accid Anal Prev· January 2013

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Measuring driver impairments: sleepiness, distraction, and workload.
Christer Ahlstrom, Katja Kircher, Carina Fors, Tania Dukic, Christopher Patten

IEEE Pulse· March 2012

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Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2.
Jie Wang, Eric T Williams, Joanne Bourgea, Y Nancy Wong, Christopher J Patten

Drug Metab Dispos· August 2011

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CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.
Yi Jin, Markus Zollinger, Hubert Borell, Alfred Zimmerlin, Christopher J Patten

Drug Metab Dispos· February 2011

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Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.
Christopher M Yates, Peter J Brown, Eugene L Stewart, Christopher Patten, Robert J H Austin

J Med Chem· June 2010

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Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.
Eva R Trösken, Magdalena Adamska, Michael Arand, Jürg A Zarn, Christopher Patten

Toxicology· November 2006

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Driver experience and cognitive workload in different traffic environments.
Christopher J D Patten, Albert Kircher, Joakim Ostlund, Lena Nilsson, Ola Svenson

Accid Anal Prev· September 2006

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In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation.
Donglu Zhang, Theodore J Chando, Donald W Everett, Christopher J Patten, Shangara S Dehal

Drug Metab Dispos· November 2005

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Characterization of pristane-induced arthritis, a murine model of chronic disease: response to antirheumatic agents, expression of joint cytokines, and immunopathology.
Christopher Patten, Katherine Bush, Inma Rioja, Rebecca Morgan, Paul Wooley

Arthritis Rheum· October 2004

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Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS.
Eva R Trösken, Ellen Straube, Werner K Lutz, Wolfgang Völkel, Christopher Patten

J Am Soc Mass Spectrom· August 2004

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Using mobile telephones: cognitive workload and attention resource allocation.
Christopher J D Patten, Albert Kircher, Joakim Ostlund, Lena Nilsson

Accid Anal Prev· May 2004

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Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible.
David M Stresser, Marc I Broudy, Thuy Ho, Catherine E Cargill, Andrew P Blanchard, Christopher J Patten

Drug Metab Dispos· January 2004

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Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism.
Michael H Court, Soundarajan Krishnaswamy, Qin Hao, Su X Duan, Christopher J Patten

Drug Metab Dispos· September 2003

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Glucuronides of tea catechins: enzymology of biosynthesis and biological activities.
Hong Lu, Xiaofeng Meng, Chuan Li, Shengmin Sang, Christopher Patten

Drug Metab Dispos· April 2003

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Assessing pregnancy risks of azole antifungals using a high throughput aromatase inhibition assay.
Laura Kragie, Stephanie D Turner, Christopher J Patten, Charles L Crespi, David M Stresser

Endocr Res· August 2002

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