Publications by authors named "Christopher Salatto"

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Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Gary E Aspnes, Steven B Coffey, Etzer Darout, Anne-Marie Dechert-Schmitt, Robert G Dullea, Christopher T Salatto

Bioorg Med Chem Lett· August 2023

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Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.
Allyn T Londregan, Liuqing Wei, Jun Xiao, Nathanael G Lintner, Donna Petersen, Christopher T Salatto

J Med Chem· July 2018

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Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.
Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes

EBioMedicine· May 2018

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
David J Edmonds, Daniel W Kung, Amit S Kalgutkar, Kevin J Filipski, David C Ebner, Christopher T Salatto

J Med Chem· March 2018

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Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Kim F McClure, David W Piotrowski, Donna Petersen, Liuqing Wei, Jun Xiao, Christopher T Salatto

Angew Chem Int Ed Engl· December 2017

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Selective Activation of AMPK 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
Christopher T Salatto, Russell A Miller, Kimberly O Cameron, Emily Cokorinos, Allan Reyes

J Pharmacol Exp Ther· May 2017

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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Emily C Cokorinos, Jake Delmore, Allan R Reyes, Bina Albuquerque, Rasmus Kjøbsted, Christopher T Salatto

Cell Metab· May 2017

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Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
Carlos A Sanhueza, Michael M Baksh, Benjamin Thuma, Marc D Roy, Sanjay Dutta, Christopher T Salatto

J Am Chem Soc· March 2017

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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, Christopher T Salatto

J Med Chem· September 2016

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Study of CRTC2 pharmacology using antisense oligonuceotides.
Robert Dullea, Christopher Salatto, Simone Sciabola, Tracy Chen, Debra Dimattia

Nucleic Acid Ther· April 2014

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The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Angel Guzman-Perez, Jeffrey A Pfefferkorn, Esther C Y Lee, Benjamin D Stevens, Gary E Aspnes, Christopher T Salatto

Bioorg Med Chem Lett· May 2013

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Chemical modification study of antisense gapmers.
Robert Stanton, Simone Sciabola, Christopher Salatto, Yan Weng, Debra Moshinsky

Nucleic Acid Ther· October 2012

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A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Kevin J Filipski, Jianwei Bian, David C Ebner, Esther C Y Lee, Jian-Cheng Li, Christopher T Salatto

Bioorg Med Chem Lett· January 2012

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Antibody-directed myostatin inhibition improves diaphragm pathology in young but not adult dystrophic mdx mice.
Kate T Murphy, James G Ryall, Sarah M Snell, Lawrence Nair, René Koopman, Christopher T Salatto

Am J Pathol· May 2010

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Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.
Thomas A Lanz, Christopher T Salatto, Anthony R Semproni, Michael Marconi, Tracy M Brown

Biochem Pharmacol· March 2008

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Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor beta and androgen receptor in rats.
Xiao-Ning Wang, Hollis A Simmons, Christopher T Salatto, Patricia G Cosgrove, David D Thompson

Menopause· October 2006

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