Publications by authors named "Christopher Savard"

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Soluble Triggering Receptor Expressed on Myeloid Cells 2 is a Biomarker but Not a Mediator of Fibrosing Steatohepatitis.
Joseph L Dempsey, Christopher Savard, Vishal Kothari, Jingjing Tang, Sum P Lee

Gastro Hep Adv· December 2025

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Soluble TREM2 is a biomarker but not a mediator of fibrosing steatohepatitis.
Joseph L Dempsey, Christopher Savard, Vishal Kothari, Jingjing Tang, Sum P Lee

bioRxiv· March 2025

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Discrimination of lipid composition and cellular localization in human liver tissues by stimulated Raman scattering microscopy.
Fiona Xi Xu, George N Ioannou, Sum P Lee, Christopher Savard, Christian L Horn

J Biomed Opt· January 2024

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sTREM2 is a plasma biomarker for human NASH and promotes hepatocyte lipid accumulation.
Vishal Kothari, Christopher Savard, Jingjing Tang, Sum P Lee, Savitha Subramanian

Hepatol Commun· November 2023

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Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH.
George N Ioannou, Christian L Horn, Vishal Kothari, Matthew M Yeh, Irene Shyu, Christopher E Savard

J Lipid Res· February 2023

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Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.
Kimberly A Jett, Zakery N Baker, Amzad Hossain, Aren Boulet, Paul A Cobine, Christopher Savard

J Clin Invest· January 2023

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Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol.
George N Ioannou, Sum P Lee, Peter S Linsley, Vivian Gersuk, Matthew M Yeh, Christopher Savard

Hepatol Commun· April 2022

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Role of Cholesterol-Associated Steatohepatitis in the Development of NASH.
Christian L Horn, Amilcar L Morales, Christopher Savard, Geoffrey C Farrell, George N Ioannou

Hepatol Commun· January 2022

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Cholesterol Crystals in Hepatocyte Lipid Droplets Are Strongly Associated With Human Nonalcoholic Steatohepatitis.
George N Ioannou, Charles S Landis, Ga-Young Jin, W Geoffrey Haigh, Geoffrey C Farrell, Christopher Savard

Hepatol Commun· June 2019

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Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH.
George N Ioannou, Savitha Subramanian, Alan Chait, W Geoffrey Haigh, Matthew M Yeh, Christopher Savard

J Lipid Res· June 2017

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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Auvro R Mridha, Alexander Wree, Avril A B Robertson, Matthew M Yeh, Casey D Johnson, Christopher Savard

J Hepatol· May 2017

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Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH.
George N Ioannou, Derrick M Van Rooyen, Christopher Savard, W Geoffrey Haigh, Matthew M Yeh

J Lipid Res· February 2015

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Anti-apoptotic phenotypes of cholestan-3β,5α,6β-triol-resistant human cholangiocytes: characteristics contributing to the genesis of cholangiocarcinoma.
Apinya Jusakul, Watcharin Loilome, Nisana Namwat, Anchalee Techasen, Rahul Kuver, Christopher Savard

J Steroid Biochem Mol Biol· November 2013

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Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis.
George N Ioannou, W Geoffrey Haigh, David Thorning, Christopher Savard

J Lipid Res· May 2013

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Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis.
Christopher Savard, Erica V Tartaglione, Rahul Kuver, W Geoffrey Haigh, Geoffrey C Farrell

Hepatology· January 2013

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Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes.
Tae-Hyeon Kim, Jong Ho Moon, Christopher E Savard, Rahul Kuver, Sum P Lee

J Gastroenterol Hepatol· July 2009

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Peripheral amyloid-beta levels regulate amyloid-beta clearance from the central nervous system.
Marcos A Marques, J Jacob Kulstad, Christopher E Savard, Pattie S Green, Sum P Lee

J Alzheimers Dis· June 2009

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Gallbladder epithelial cells that engraft in mouse liver can differentiate into hepatocyte-like cells.
Sum P Lee, Christopher E Savard, Rahul Kuver

Am J Pathol· March 2009

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Murine gallbladder epithelial cells can differentiate into hepatocyte-like cells in vitro.
Rahul Kuver, Christopher E Savard, Sung Koo Lee, W Geoffrey Haigh, Sum P Lee

Am J Physiol Gastrointest Liver Physiol· November 2007

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Paclitaxel interrupts TGF-beta1 signaling between gallbladder epithelial cells and myofibroblasts.
Ho-Soon Choi, Christopher E Savard, Jae-Woon Choi, Rahul Kuver, Sum P Lee

J Surg Res· August 2007

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Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by gallbladder epithelial cells: response to bacterial lipopolysaccharides.
Christopher E Savard, Thane A Blinman, Ho-Soon Choi, Sung-Koo Lee, Stephen J Pandol

BMC Gastroenterol· October 2002

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Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.
Tina W f Yen, Nils Petter Aardal, Mary P Bronner, David R Thorning, Christopher E Savard

Surgery· February 2002

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