Publications by authors named "Christopher Theile"

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Expanding the binding space of argonaute-2: incorporation of either or isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.
Dhrubajyoti Datta, Jayanta Kundu, Patrick Miller, Mehreen S Khan, Juan Salinas, Christopher S Theile

Chem Commun (Camb)· April 2025

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Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.
Krishna C Aluri, Dhrubajyoti Datta, Scott Waldron, Nate Taneja, June Qin, Christopher S Theile

J Am Chem Soc· October 2024

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Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
Mikyung Yu, June Qin, Xiumin Liu, Diane Ramsden, Brian Williams, Christopher S Theile

Nucleic Acids Res· June 2024

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Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Christopher S Theile

J Am Chem Soc· September 2023

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Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
Dhrubajyoti Datta, Christopher S Theile, Kelly Wassarman, June Qin, Tim Racie

Chem Commun (Camb)· May 2023

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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Kirk M Brown, Jayaprakash K Nair, Maja M Janas, Yesseinia I Anglero-Rodriguez, Lan T H Dang, Christopher S Theile

Nat Biotechnol· October 2022

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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of -Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human.
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Christopher Theile

Drug Metab Dispos· June 2022

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Centyrin ligands for extrahepatic delivery of siRNA.
Donna Klein, Shalom Goldberg, Christopher S Theile, Richard Dambra, Kathleen Haskell

Mol Ther· June 2021

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Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Christopher R Brown, Swati Gupta, June Qin, Timothy Racie, Guo He, Christopher S Theile

Nucleic Acids Res· December 2020

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Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity.
Sonia Fieulaine, Martin D Witte, Christopher S Theile, Maya Ayach, Hidde L Ploegh

J Biol Chem· October 2020

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Generation and validation of structurally defined antibody-siRNA conjugates.
Alex R Nanna, Alexander V Kel'in, Christopher Theile, Justin M Pierson, Zhi Xiang Voo

Nucleic Acids Res· June 2020

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Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.
Rubina Giare Parmar, Christopher R Brown, Shigeo Matsuda, Jennifer L S Willoughby, Christopher S Theile

J Med Chem· February 2018

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siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
Elad Elkayam, Rubina Parmar, Christopher R Brown, Jennifer L Willoughby, Christopher S Theile

Nucleic Acids Res· May 2017

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siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
Elad Elkayam, Rubina Parmar, Christopher R Brown, Jennifer L Willoughby, Christopher S Theile

Nucleic Acids Res· April 2017

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Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.
Guan-Yu Chen, Zeyang Li, Joao N Duarte, Alexandre Esteban, Ross W Cheloha, Christopher S Theile

Biosens Bioelectron· March 2017

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5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
Rubina Parmar, Jennifer L S Willoughby, Jingxuan Liu, Donald J Foster, Benjamin Brigham, Christopher S Theile

Chembiochem· June 2016

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Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Akhee S Jahan, Maxime Lestra, Lee Kim Swee, Ying Fan, Mart M Lamers, Christopher S Theile

Proc Natl Acad Sci U S A· February 2016

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Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.
Irene Wuethrich, Janneke G C Peeters, Annet E M Blom, Christopher S Theile, Zeyang Li

PLoS One· December 2015

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Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells.
Guan-Yu Chen, Zeyang Li, Christopher S Theile, Neelkanth M Bardhan, Priyank V Kumar

Chemistry· November 2015

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Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments.
Zeyang Li, Christopher S Theile, Guan-Yu Chen, Angelina M Bilate, Joao N Duarte

Angew Chem Int Ed Engl· September 2015

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Site-specific protein modification using immobilized sortase in batch and continuous-flow systems.
Martin D Witte, Tongfei Wu, Carla P Guimaraes, Christopher S Theile, Annet E M Blom

Nat Protoc· March 2015

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A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.
Brandon J Walters, Jada J Hallengren, Christopher S Theile, Hidde L Ploegh, Scott M Wilson

J Physiol· February 2014

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Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.
Ana M Avalos, Angelina M Bilate, Martin D Witte, Albert K Tai, Jiang He, Christopher S Theile

J Exp Med· February 2014

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Site-specific N-terminal labeling of proteins using sortase-mediated reactions.
Christopher S Theile, Martin D Witte, Annet E M Blom, Lenka Kundrat, Hidde L Ploegh

Nat Protoc· September 2013

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Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry.
Martin D Witte, Christopher S Theile, Tongfei Wu, Carla P Guimaraes, Annet E M Blom

Nat Protoc· September 2013

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