Publications by authors named "Christopher Willits"

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Christopher Willits

J Med Chem· July 2013

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Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.
Kent Fitzgerald, Marcelle Bergeron, Christopher Willits, Simeon Bowers, Danielle L Aubele

Toxicol Appl Pharmacol· May 2013

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Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.
Ken Flanagan, Kent Fitzgerald, Jeanne Baker, Karin Regnstrom, Shyra Gardai, Christopher Willits

PLoS One· April 2013

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Development of ALZET® osmotic pump compatible solvent compositions to solubilize poorly soluble compounds for preclinical studies.
Rampurna Gullapalli, Angelina Wong, Elizabeth Brigham, Grace Kwong, Angie Wadsworth, Christopher Willits

Drug Deliv· December 2012

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