Publications by authors named "Elizabeth Brigham"

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Improving pediatric trauma care at a level 1 pediatric trauma center through the multi-year implementation of a Pediatric Trauma Boot Camp curriculum.
Elizabeth M Brigham, Erica I Hodgman, Nicole A Shilkofski, Justin M Jeffers, Daniel An

Adv Simul (Lond)· June 2025

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Onset of efficacy of azelastine hydrochloride 0.15% nasal spray for allergic rhinitis in an environmental exposure chamber.
Shu-Ning Hsu, Fatima Sajjad, Elizabeth Brigham, Robert Centofanti, Robert An

Ann Allergy Asthma Immunol· December 2024

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School Nurses on the Front Lines of Healthcare: Emergencies Associated With Sport and Physical Activities (Part 4)-The Assessment of Pediatric Shoulder and Hip Injuries Utilizing the "SPASMS" Mnemonic.
Elizabeth Brigham, Robert P Olympia

NASN Sch Nurse· November 2022

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The Ignorance of Youth.
Elizabeth M Brigham

Fam Med· January 2021

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Clinical Reasoning: An adolescent girl presenting with worsening vertigo, headache, and ataxia.
Elizabeth Brigham, Chichun Sun, Richard Bronnenkant, Ashutosh Kumar, Kristin Disori

Neurology· September 2020

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School Nurses on the Front Lines of Medicine: Emergencies Associated With Sport and Physical Activities: Part 1.
Elizabeth Brigham, Jodi Brady, Robert P Olympia

NASN Sch Nurse· May 2019

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Freedom to Fly.
Elizabeth Brigham

J Grad Med Educ· April 2019

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Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia.
Elizabeth F Brigham, Tom H Johnston, Carl Brown, Jonathon D S Holt, Susan H Fox

J Pharmacol Exp Ther· November 2018

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Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis.
Elizabeth M Brigham, Douglas G Armstrong

Spine Deform· January 2017

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Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.
Andrea Giacomini, Fiorenza Stagni, Stefania Trazzi, Sandra Guidi, Marco Emili, Elizabeth Brigham

Neurobiol Dis· October 2015

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Like Father, Like Son: Cleidocranial Dysplasia: A Case Report.
Elizabeth M Brigham, William L Hennrikus

JBJS Case Connect· January 2015

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Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis.
Daniel Ness, Zhao Ren, Shyra Gardai, Douglas Sharpnack, Victor J Johnson, Elizabeth F Brigham

PLoS One· January 2014

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Elizabeth F Brigham

J Med Chem· July 2013

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Albert W Garofalo, Marc Adler, Danielle L Aubele, Elizabeth F Brigham, David Chian

Bioorg Med Chem Lett· April 2013

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Xiaocong M Ye, Andrei W Konradi, Minghua Sun, Shendong Yuan, Danielle L Aubele, Elizabeth Brigham

Bioorg Med Chem Lett· February 2013

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Development of ALZET® osmotic pump compatible solvent compositions to solubilize poorly soluble compounds for preclinical studies.
Rampurna Gullapalli, Angelina Wong, Elizabeth Brigham, Grace Kwong, Angie Wadsworth

Drug Deliv· December 2012

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The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.
Inger Lauritzen, Raphaëlle Pardossi-Piquard, Charlotte Bauer, Elizabeth Brigham, Jean-Daniel Abraham

J Neurosci· November 2012

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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Danielle L Aubele, Anh P Truong, Darren B Dressen, Gary D Probst, Simeon Bowers, Elizabeth F Brigham

Bioorg Med Chem Lett· October 2011

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Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Martin L Neitzel, Danielle L Aubele, Jennifer L Marugg, Jacek J Jagodzinski, Andrei W Konradi, Elizabeth F Brigham

Bioorg Med Chem Lett· June 2011

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Simeon Bowers, Anh P Truong, R Jeffrey Neitz, Martin Neitzel, Gary D Probst, Elizabeth F Brigham

Bioorg Med Chem Lett· March 2011

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele

Alzheimers Res Ther· December 2010

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Anh P Truong, Gergley Tóth, Gary D Probst, Jennifer M Sealy, Simeon Bowers, Elizabeth F Brigham

Bioorg Med Chem Lett· November 2010

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).
Xiaocong M Ye, Andrei W Konradi, Jenifer Smith, Danielle L Aubele, Albert W Garofalo, Elizabeth F Brigham

Bioorg Med Chem Lett· June 2010

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Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Matthew N Mattson, Martin L Neitzel, David A Quincy, Christopher M Semko, Albert W Garofalo, Elizabeth F Brigham

Bioorg Med Chem Lett· April 2010

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
Xiaocong M Ye, Andrei W Konradi, Jenifer Smith, Ying-Zi Xu, Darren Dressen, Elizabeth Brigham

Bioorg Med Chem Lett· April 2010

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