Publications by authors named "Gary D Probst"

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Raymond A Ng, Minghua Sun, Simeon Bowers, Roy K Hom, Gary D Probst

Bioorg Med Chem Lett· August 2013

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Albert W Garofalo, Marc Adler, Danielle L Aubele, Elizabeth F Brigham, David Chian, Gary D Probst

Bioorg Med Chem Lett· April 2013

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Triazolopyridazine LRRK2 kinase inhibitors.
Maurizio Franzini, Xiaocong M Ye, Marc Adler, Danielle L Aubele, Albert W Garofalo, Gary D Probst

Bioorg Med Chem Lett· April 2013

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Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Simeon Bowers, Ying-zi Xu, Shendong Yuan, Gary D Probst, Roy K Hom

Bioorg Med Chem Lett· April 2013

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Xiaocong M Ye, Andrei W Konradi, Minghua Sun, Shendong Yuan, Danielle L Aubele, Gary D Probst

Bioorg Med Chem Lett· February 2013

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Novel cinnoline-based inhibitors of LRRK2 kinase activity.
Albert W Garofalo, Marc Adler, Danielle L Aubele, Simeon Bowers, Maurizio Franzini, Gary D Probst

Bioorg Med Chem Lett· January 2013

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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Danielle L Aubele, Anh P Truong, Darren B Dressen, Gary D Probst, Simeon Bowers

Bioorg Med Chem Lett· October 2011

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Simeon Bowers, Anh P Truong, R Jeffrey Neitz, Roy K Hom, Jennifer M Sealy, Gary D Probst

Bioorg Med Chem Lett· September 2011

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Simeon Bowers, Anh P Truong, R Jeffrey Neitz, Martin Neitzel, Gary D Probst

Bioorg Med Chem Lett· March 2011

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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Gary D Probst, Simeon Bowers, Jennifer M Sealy, Anh P Truong, Roy K Hom

Bioorg Med Chem Lett· January 2011

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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Roy K Hom, Simeon Bowers, Jennifer M Sealy, Anh P Truong, Gary D Probst

Bioorg Med Chem Lett· December 2010

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Anh P Truong, Gergley Tóth, Gary D Probst, Jennifer M Sealy, Simeon Bowers

Bioorg Med Chem Lett· November 2010

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Gary D Probst, Simeon Bowers, Jennifer M Sealy, Brian Stupi, Darren Dressen

Bioorg Med Chem Lett· October 2010

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Anh P Truong, Gary D Probst, Jose Aquino, Larry Fang, Louis Brogley

Bioorg Med Chem Lett· August 2010

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N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.
Simeon Bowers, Gary D Probst, Anh P Truong, Roy K Hom, Andrei W Konradi

Bioorg Med Chem Lett· December 2009

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Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Jennifer M Sealy, Anh P Truong, Luke Tso, Gary D Probst, Jose Aquino

Bioorg Med Chem Lett· November 2009

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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Anh P Truong, Danielle L Aubele, Gary D Probst, Martin L Neitzel, Chris M Semko

Bioorg Med Chem Lett· September 2009

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.
Penglie Zhang, Wenrong Huang, Lingyan Wang, Liang Bao, Zhaozhong J Jia, Gary D Probst

Bioorg Med Chem Lett· April 2009

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A formal synthesis of (-)-mycalamide A.
Barry M Trost, Hanbiao Yang, Gary D Probst

J Am Chem Soc· January 2004

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