Publications by authors named "Ying-zi Xu"

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A computational and functional study elicits the ameliorating effect of the Chinese herbal formula Huo Luo Xiao Ling Dan on experimental ischemia-induced myocardial injury in rats via inhibition of apoptosis.
Xiang-Dong Han, Zhi-Wei Zhou, Wei Yang, Hang-Cheng Ye, Ying-Zi Xu

Drug Des Devel Ther· August 2016

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Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors.
Kalyani Mondal, Karin Regnstrom, Winse Morishige, Robin Barbour, Gary Probst, Ying-Zi Xu

Biochem Biophys Res Commun· November 2013

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Orally available and efficacious α4β1/α4β7 integrin inhibitors.
Ying-zi Xu, Jenifer L Smith, Christopher M Semko, Kassandra I Rossiter, Juri Y Fukuda

Bioorg Med Chem Lett· August 2013

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Development of a novel β-secretase binding assay using the AlphaScreen platform.
Zhao Ren, Danny Tam, Ying-Zi Xu, David Wone, Shendong Yuan

J Biomol Screen· July 2013

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Ying-Zi Xu

J Med Chem· July 2013

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PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration.
Jenifer L Smith, Kassandra I Rossiter, Christopher M Semko, Ying-Zi Xu, David A Quincy

Bioorg Med Chem Lett· July 2013

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Arylsulfonamide pyrimidines as VLA-4 antagonists.
Ying-Zi Xu, Andrei W Konradi, Frederique Bard, Michael Dappen, Lilibeth Dofiles

Bioorg Med Chem Lett· May 2013

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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Ying-Zi Xu, Shendong Yuan, Simeon Bowers, Roy K Hom, Wayman Chan

Bioorg Med Chem Lett· May 2013

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Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Simeon Bowers, Ying-zi Xu, Shendong Yuan, Gary D Probst, Roy K Hom

Bioorg Med Chem Lett· April 2013

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Xiaocong M Ye, Andrei W Konradi, Minghua Sun, Shendong Yuan, Danielle L Aubele, Ying-zi Xu

Bioorg Med Chem Lett· February 2013

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Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).
Gary Probst, Ying-zi Xu

Expert Opin Ther Pat· May 2012

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A label-free approach to identify inhibitors of alpha4beta7-mediated cell adhesion to MadCAM.
Michael P Bova, Lan Nguyen, William Wallace, Caroline Garrido, Ying-Zi Xu

J Biomol Screen· June 2011

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Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model.
Christopher M Semko, Linda Chen, Darren B Dressen, Mark L Dreyer, Whitney Dunn, Ying-Zi Xu

Bioorg Med Chem Lett· March 2011

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele, Ying-Zi Xu

Alzheimers Res Ther· December 2010

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Gary D Probst, Simeon Bowers, Jennifer M Sealy, Brian Stupi, Darren Dressen, Ying-Zi Xu

Bioorg Med Chem Lett· October 2010

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.
Xiaocong M Ye, Andrei W Konradi, Jenifer Smith, Ying-Zi Xu, Darren Dressen

Bioorg Med Chem Lett· April 2010

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