Publications by authors named "Martin Neitzel"

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Martin L Neitzel

J Med Chem· July 2013

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Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Martin L Neitzel, Danielle L Aubele, Jennifer L Marugg, Jacek J Jagodzinski, Andrei W Konradi

Bioorg Med Chem Lett· June 2011

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Simeon Bowers, Anh P Truong, R Jeffrey Neitz, Martin Neitzel, Gary D Probst

Bioorg Med Chem Lett· March 2011

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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Roy K Hom, Simeon Bowers, Jennifer M Sealy, Anh P Truong, Gary D Probst, Martin L Neitzel

Bioorg Med Chem Lett· December 2010

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele, Martin L Neitzel

Alzheimers Res Ther· December 2010

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Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Matthew N Mattson, Martin L Neitzel, David A Quincy, Christopher M Semko, Albert W Garofalo

Bioorg Med Chem Lett· April 2010

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Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.
Anh P Truong, Danielle L Aubele, Gary D Probst, Martin L Neitzel, Chris M Semko

Bioorg Med Chem Lett· September 2009

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Identification of gamma-secretase inhibitor potency determinants on presenilin.
Byron Zhao, Mei Yu, Martin Neitzel, Jennifer Marugg, Jacek Jagodzinski

J Biol Chem· February 2008

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Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists.
Darren Dressen, Albert W Garofalo, Jon Hawkinson, Dennis Hom, Jacek Jagodzinski, Martin L Neitzel

J Med Chem· October 2007

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