Publications by authors named "Matthew N Mattson"

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Matthew N Mattson

J Med Chem· July 2013

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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Danielle L Aubele, Anh P Truong, Darren B Dressen, Gary D Probst, Simeon Bowers, Matthew N Mattson

Bioorg Med Chem Lett· October 2011

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele, Matthew N Mattson

Alzheimers Res Ther· December 2010

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Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.
Matthew N Mattson, Martin L Neitzel, David A Quincy, Christopher M Semko, Albert W Garofalo

Bioorg Med Chem Lett· April 2010

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Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.
Michael P Bova, Danny Tam, Gerald McMahon, Matthew N Mattson

Toxicol Lett· January 2005

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The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.
Michael P Bova, Matthew N Mattson, Stefan Vasile, Danny Tam, Leslie Holsinger

Arch Biochem Biophys· September 2004

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Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate.
Kenneth G Holden, Matthew N Mattson, Kyung Hoi Cha, Henry Rapoport

J Org Chem· August 2002

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