Publications by authors named "Claude Ambroise"

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Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators.
Thomas A Chappie, Mario Abdelmessih, Claude W Ambroise, Markus Boehm, Mi Cai

ACS Med Chem Lett· January 2022

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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
Brian T O'Neill, Elizabeth M Beck, Christopher R Butler, Charles E Nolan, Cathleen Gonzales, Claude W Ambroise

J Med Chem· May 2018

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Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors.
Andrea M Zuhl, Charles E Nolan, Michael A Brodney, Sherry Niessen, Kevin Atchison, Claude Ambroise

Nat Commun· October 2016

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Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.
Zdenek Berger, Sarah Perkins, Claude Ambroise, Christine Oborski, Matthew Calabrese

PLoS One· November 2015

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Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
Michael A Brodney, Gabriela Barreiro, Kevin Ogilvie, Eva Hajos-Korcsok, John Murray, Claude Ambroise

J Med Chem· November 2012

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The B73 maize genome: complexity, diversity, and dynamics.
Patrick S Schnable, Doreen Ware, Robert S Fulton, Joshua C Stein, Fusheng Wei, Claude Ambroise

Science· November 2009

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