Publications by authors named "Matthew Calabrese"

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Applications of contemporary tools to measure plasma protein binding of targeted protein degraders.
Mark Niosi, Sam Zhang, Woodrow Burchett, Carley J S Heck, Gilles H Goetz, Matthew F Calabrese

Drug Metab Dispos· May 2025

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A Systematic Blueprint to Ligand the Proteome.
Matthew F Calabrese

J Med Chem· January 2025

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A chemical probe to modulate human GID4 Pro/N-degron interactions.
Dominic D G Owens, Matthew E R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Viviane Reber, Matthew F Calabrese

Nat Chem Biol· September 2024

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Structural basis for CCR6 modulation by allosteric antagonists.
David Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, Wei Li, Jennifer Alley, Matthew F Calabrese

Nat Commun· August 2024

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Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.
Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Matthew F Calabrese

RSC Med Chem· March 2024

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A covalent BTK ternary complex compatible with targeted protein degradation.
James Schiemer, Andrew Maxwell, Reto Horst, Shenping Liu, Daniel P Uccello, Matthew F Calabrese

Nat Commun· March 2023

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Structural basis of the acyl-transfer mechanism of human GPAT1.
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Matthew Calabrese

Nat Struct Mol Biol· January 2023

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Perspectives on the development of first-in-class protein degraders.
Kalyn M Rambacher, Matthew F Calabrese, Masaya Yamaguchi

Future Med Chem· July 2021

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes.
James Schiemer, Reto Horst, Yilin Meng, Justin I Montgomery, Yingrong Xu, Matthew F Calabrese

Nat Chem Biol· February 2021

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Targeted protein degradation: expanding the toolbox.
Matthieu Schapira, Matthew F Calabrese, Alex N Bullock, Craig M Crews

Nat Rev Drug Discov· December 2019

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Biophysical Interactions of Direct AMPK Activators.
Ravi G Kurumbail, Graham M West, Venkatasubramanian Dharmarajan, Kris A Borzilleri, Jane M Withka, Matthew F Calabrese

Methods Mol Biol· January 2019

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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Tim F Ryder, Matthew F Calabrese, Gregory S Walker, Kimberly O Cameron, Allan R Reyes

J Med Chem· August 2018

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Delineating the role of cooperativity in the design of potent PROTACs for BTK.
Adelajda Zorba, Chuong Nguyen, Yingrong Xu, Jeremy Starr, Kris Borzilleri, Matthew F Calabrese

Proc Natl Acad Sci U S A· July 2018

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
David J Edmonds, Daniel W Kung, Amit S Kalgutkar, Kevin J Filipski, David C Ebner, Matthew F Calabrese

J Med Chem· March 2018

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Structure and Regulation of AMPK.
Ravi G Kurumbail, Matthew F Calabrese

Exp Suppl· June 2017

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Selective Activation of AMPK 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
Christopher T Salatto, Russell A Miller, Kimberly O Cameron, Emily Cokorinos, Allan Reyes, Matthew F Calabrese

J Pharmacol Exp Ther· May 2017

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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Emily C Cokorinos, Jake Delmore, Allan R Reyes, Bina Albuquerque, Rasmus Kjøbsted, Matthew F Calabrese

Cell Metab· May 2017

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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, Matthew Calabrese

J Med Chem· September 2016

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Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.
Francis Rajamohan, Allan R Reyes, Richard K Frisbie, Lise R Hoth, Parag Sahasrabudhe, Matthew F Calabrese

Biochem J· March 2016

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Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.
Zdenek Berger, Sarah Perkins, Claude Ambroise, Christine Oborski, Matthew Calabrese

PLoS One· November 2015

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Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Matthew F Calabrese, Francis Rajamohan, Melissa S Harris, Nicole L Caspers, Rachelle Magyar

Structure· August 2014

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SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Ruby Dhar, Matthew F Calabrese

Cancer Cell· April 2014

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Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.
Rachelle R Landgraf, Devrishi Goswami, Francis Rajamohan, Melissa S Harris, Matthew F Calabrese

Structure· November 2013

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SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.
Achim Werner, Andrea Disanza, Nina Reifenberger, Gregor Habeck, Janina Becker, Matthew Calabrese

Nat Cell Biol· February 2013

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A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
Matthew F Calabrese, Daniel C Scott, David M Duda, Christy R R Grace, Igor Kurinov

Nat Struct Mol Biol· July 2011

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