Publications by authors named "Jeremy Starr"

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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M Muscarinic Acetylcholine Receptor.
Christopher R Butler, Michael Popiolek, Laura A McAllister, Erik A LaChapelle, Melissa Kramer, Jeremy Starr

J Med Chem· July 2024

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
Guoyun Bai, Thomas N O'Connell, Michael A Brodney, Christopher R Butler, Lara C Czabaniuk, Jeremy T Starr

ACS Med Chem Lett· October 2021

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Synthesis of PEG-Functionalized Amines Using Ruthenium-Catalyzed Hydrogen Borrowing.
Federico V Rossi, Jeremy T Starr, Daniel P Uccello, Jennifer A Young

Org Lett· August 2020

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Late-Stage Lead Diversification Coupled with Quantitative Nuclear Magnetic Resonance Spectroscopy to Identify New Structure-Activity Relationship Vectors at Nanomole-Scale Synthesis: Application to Loratadine, a Human Histamine H Receptor Inverse Agonist.
Manjinder S Lall, Asser Bassyouni, James Bradow, Maria Brown, Mark Bundesmann, Jeremy Starr

J Med Chem· July 2020

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Hindered dialkyl ether synthesis with electrogenerated carbocations.
Jinbao Xiang, Ming Shang, Yu Kawamata, Helena Lundberg, Solomon H Reisberg, Jeremy Starr

Nature· September 2019

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Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications.
Yu Kawamata, Julien C Vantourout, David P Hickey, Peng Bai, Longrui Chen, Jeremy T Starr

J Am Chem Soc· April 2019

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Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry.
Byron K Peters, Kevin X Rodriguez, Solomon H Reisberg, Sebastian B Beil, David P Hickey, Jeremy Starr

Science· February 2019

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Delineating the role of cooperativity in the design of potent PROTACs for BTK.
Adelajda Zorba, Chuong Nguyen, Yingrong Xu, Jeremy Starr, Kris Borzilleri

Proc Natl Acad Sci U S A· July 2018

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Electrochemically Enabled, Nickel-Catalyzed Amination.
Chao Li, Yu Kawamata, Hugh Nakamura, Julien C Vantourout, Zhiqing Liu, Jeremy T Starr

Angew Chem Int Ed Engl· October 2017

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Novel Methods for Prioritizing "Close-In" Analogs from Structure-Activity Relationship Matrices.
Liying Zhang, Kjell Johnson, Jeremy Starr, Jared Milbank, Andrew M Kuhn

J Chem Inf Model· July 2017

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Scalable, Electrochemical Oxidation of Unactivated C-H Bonds.
Yu Kawamata, Ming Yan, Zhiqing Liu, Deng-Hui Bao, Jinshan Chen, Jeremy T Starr

J Am Chem Soc· June 2017

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Hydropyridylation of Olefins by Intramolecular Minisci Reaction.
Samuele Bordi, Jeremy T Starr

Org Lett· May 2017

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Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.
Kay Ahn, Markus Boehm, Matthew F Brown, Jessica Calloway, Ye Che, Jeremy T Starr

ACS Chem Biol· September 2016

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Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.
Shenping Liu, Leslie A Dakin, Li Xing, Jane M Withka, Parag V Sahasrabudhe, Jeremy T Starr

Sci Rep· August 2016

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Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.
Mark E Flanagan, Joseph A Abramite, Dennis P Anderson, Ann Aulabaugh, Upendra P Dahal, Jeremy Starr

J Med Chem· December 2014

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One-pot oxidation and rearrangement of propargylamines and in situ pyrazole synthesis.
Jinshan Chen, Roberta Properzi, Daniel P Uccello, Jennifer A Young, Russell G Dushin, Jeremy T Starr

Org Lett· August 2014

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Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
Jeremy Starr, Matthew F Brown, Lisa Aschenbrenner, Nicole Caspers, Ye Che

J Med Chem· May 2014

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Pyridone-conjugated monobactam antibiotics with gram-negative activity.
Matthew F Brown, Mark J Mitton-Fry, Joel T Arcari, Rose Barham, Jeffrey Casavant, Jeremy T Starr

J Med Chem· July 2013

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Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
Thomas V Magee, Matthew F Brown, Jeremy T Starr, David C Ackley, Joseph A Abramite

J Med Chem· June 2013

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Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.
Mark J Mitton-Fry, Joel T Arcari, Matthew F Brown, Jeffrey M Casavant, Steven M Finegan, Jeremy T Starr

Bioorg Med Chem Lett· September 2012

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Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.
Jun Yong Choi, Mark S Plummer, Jeremy Starr, Charlene R Desbonnet, Holly Soutter

J Med Chem· January 2012

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5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.
Jeremy T Starr, Richard J Sciotti, Debra L Hanna, Michael D Huband, Lisa M Mullins

Bioorg Med Chem Lett· September 2009

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One-pot synthesis of N-arylpyrazoles from arylhalides.
Brian S Gerstenberger, Mark R Rauckhorst, Jeremy T Starr

Org Lett· May 2009

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The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents.
Sean T Murphy, Heather L Case, Edmund Ellsworth, Susan Hagen, Michael Huband, Jeremy Starr

Bioorg Med Chem Lett· April 2007

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A cycloaddition cascade approach to the total synthesis of (-)-FR182877.
David A Evans, Jeremy T Starr

J Am Chem Soc· November 2003

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