Publications by authors named "Sean T Murphy"

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Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease.
Mahta Barekatain, Linda C Johansson, Jordy H Lam, Hao Chang, Anastasiia V Sadybekov, Sean T Murphy

Sci Signal· December 2024

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Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo Efficacy.
Sean T Murphy, Joy Atienza, Jason W Brown, Zacharia S Cheruvallath, Matthew J Cukierski

ACS Med Chem Lett· November 2023

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First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate.
Huikai Sun, Holger Monenschein, Hans H Schiffer, Holly A Reichard, Shota Kikuchi, Sean T Murphy

J Med Chem· July 2021

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Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease.
Nicola L Brice, Hans H Schiffer, Holger Monenschein, Victoria J Mulligan, Keith Page, Sean T Murphy

J Pharmacol Exp Ther· June 2021

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Would the control of invasive alien plants reduce malaria transmission? A review.
Christopher M Stone, Arne B R Witt, Guillermo Cabrera Walsh, Woodbridge A Foster, Sean T Murphy

Parasit Vectors· February 2018

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Time-dependent inhibition of PHD2.
Isabelle Tcholakov, Charles E Grimshaw, Lihong Shi, Andre Kiryanov, Sean T Murphy

Biosci Rep· June 2017

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The Invasive Liriomyza huidobrensis (Diptera: Agromyzidae): Understanding Its Pest Status and Management Globally.
Phyllis G Weintraub, Sonja J Scheffer, Diedrich Visser, Graciela Valladares, Alberto Soares Correa, Sean T Murphy

J Insect Sci· January 2017

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Impacts of an invasive non-native annual weed, Impatiens glandulifera, on above- and below-ground invertebrate communities in the United Kingdom.
Robert A Tanner, Sonal Varia, René Eschen, Suzy Wood, Sean T Murphy

PLoS One· January 2014

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Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells.
Sangita M Baxi, Wei Tan, Sean T Murphy, Tod Smeal, Min-Jean Yin

PLoS One· April 2013

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Stereoselective synthesis of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile.
Manjinder S Lall, Garrett Hoge, Tuan P Tran, William Kissel, Sean T Murphy

J Org Chem· May 2012

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Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC.
Joseph S Warmus, Cheryl L Quinn, Clarke Taylor, Sean T Murphy, Timothy A Johnson

Bioorg Med Chem Lett· April 2012

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Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
Sean T Murphy, Gordon Alton, Simon Bailey, Sangita M Baxi, Benjamin J Burke

J Med Chem· December 2011

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Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays.
Alexandra Hofler, Tim Nichols, Stephan Grant, Laura Lingardo, Edward A Esposito, Sean T Murphy

Anal Biochem· July 2011

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Reproductive biology of two nontarget insect species, Aphis gossypii (Homoptera: Aphididae) and Orius sauteri (Hemiptera: Anthocoridae), on Bt and non-Bt cotton cultivars.
Gui-Fen Zhang, Fang-Hao Wan, Sean T Murphy, Jian-Ying Guo, Wan-Xue Liu

Environ Entomol· August 2008

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Prediction of drug degradants using DELPHI: an expert system for focusing knowledge.
David L Pole, Howard Y Ando, Sean T Murphy

Mol Pharm· September 2007

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The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents.
Sean T Murphy, Heather L Case, Edmund Ellsworth, Susan Hagen, Michael Huband

Bioorg Med Chem Lett· April 2007

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