Publications by authors named "Gordon Alton"

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A rifamycin SV in situ gelling formulation for the treatment of pouchitis.
Katia Mangano, Cinzia Quatrocchi, Katia Ajello, Stefania Pagani, Gordon Alton

Drug Deliv Transl Res· September 2025

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VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease.
Leo R Fitzpatrick, Jeff Small, Robert O'Connell, George Talbott, Gordon Alton

Inflammopharmacology· April 2020

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Novel small molecule inhibitors of the OLIG2 transcription factor: promising new therapeutics for glioblastoma.
Gordon Alton, Santosh Kesari

Future Oncol· December 2016

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Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
Sean T Murphy, Gordon Alton, Simon Bailey, Sangita M Baxi, Benjamin J Burke

J Med Chem· December 2011

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Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK).
J Jean Cui, Michelle Tran-Dubé, Hong Shen, Mitchell Nambu, Pei-Pei Kung, Gordon Alton

J Med Chem· September 2011

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Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays.
Alexandra Hofler, Tim Nichols, Stephan Grant, Laura Lingardo, Edward A Esposito, Gordon Alton

Anal Biochem· July 2011

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Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery.
M Catherine Johnson, Qiyue Hu, Laura Lingardo, Rose Ann Ferre, Samantha Greasley, Gordon Alton

J Comput Aided Mol Des· July 2011

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Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors.
Hui Li, Yufeng Hong, Seiji Nukui, Jihong Lou, Sarah Johnson, Gordon Alton

Bioorg Med Chem Lett· January 2011

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Potent and selective thiophene urea-templated inhibitors of S6K.
Ping Ye, Cyrille Kuhn, Miret Juan, Rahul Sharma, Brendan Connolly, Gordon Alton

Bioorg Med Chem Lett· January 2011

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Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).
Laura R Pearce, Gordon R Alton, Daniel T Richter, John C Kath, Laura Lingardo

Biochem J· October 2010

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Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function.
Yunpeng Du, Jie Tang, Guangyuan Li, Liliana Berti-Mattera, Chieh Allen Lee, Gordon Alton

Invest Ophthalmol Vis Sci· April 2010

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Characterization of the CHK1 allosteric inhibitor binding site.
Darin Vanderpool, Ted O Johnson, Chen Ping, Simon Bergqvist, Gordon Alton

Biochemistry· October 2009

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Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.
Sergei L Timofeevski, Michele A McTigue, Kevin Ryan, Jean Cui, Helen Y Zou, Gordon Alton

Biochemistry· June 2009

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Structure activity relationships of quinoline-containing c-Met inhibitors.
Pei-Pei Kung, Lee Funk, Jerry Meng, Gordon Alton, Ellen Padrique

Eur J Med Chem· June 2008

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Targeting the unactivated conformations of protein kinases for small molecule drug discovery.
Gordon R Alton, Elizabeth A Lunney

Expert Opin Drug Discov· June 2008

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Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.
James G Christensen, Helen Y Zou, Maria E Arango, Qiuhua Li, Joseph H Lee, Gordon R Alton

Mol Cancer Ther· December 2007

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Assay optimization and kinetic profile of the human and the rabbit isoforms of 11beta-HSD1.
Arturo Castro, Jeff X Zhu, Gordon R Alton, Paul Rejto, Jacques Ermolieff

Biochem Biophys Res Commun· June 2007

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An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.
Helen Y Zou, Qiuhua Li, Joseph H Lee, Maria E Arango, Scott R McDonnell, Gordon Alton

Cancer Res· May 2007

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Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane.
Mahnaz Razandi, Gordon Alton, Ali Pedram, Sanjiv Ghonshani, Paul Webb

Mol Cell Biol· March 2003

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Therapeutic modulation of inflammatory gene transcription by kinase inhibitors.
Gordon Alton, Klaus Schwamborn, Yoshi Satoh, John K Westwick

Expert Opin Biol Ther· August 2002

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Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase.
Joseph A Davis, Xiao-Hua Wu, Ling Wang, Charles DeRossi, Vibeke Westphal, Gordon Alton

Glycobiology· July 2002

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