Publications by authors named "Darin Vanderpool"

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The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading.
Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D Engstrom, Jade Laguer, Darin Vanderpool

Mol Cancer Ther· October 2024

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MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.
Lars D Engstrom, Ruth Aranda, Laura Waters, Krystal Moya, Vickie Bowcut, Darin Vanderpool

Cancer Discov· November 2023

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Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo Efficacy.
Sean T Murphy, Joy Atienza, Jason W Brown, Zacharia S Cheruvallath, Matthew J Cukierski, Darin L Vanderpool

ACS Med Chem Lett· November 2023

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Anti-tumor efficacy of a potent and selective non-covalent KRAS inhibitor.
Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M Briere, Lauren Hargis, Darin Vanderpool

Nat Med· October 2022

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Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.
John M Ketcham, Jacob Haling, Shilpi Khare, Vickie Bowcut, David M Briere, Darin Vanderpool

J Med Chem· July 2022

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Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS Inhibitor.
Xiaolun Wang, Shelley Allen, James F Blake, Vickie Bowcut, David M Briere, Darin Vanderpool

J Med Chem· February 2022

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Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2.
Christopher McBride, Zacharia Cheruvallath, Mallareddy Komandla, Mingnam Tang, Pamela Farrell, Darin Vanderpool

Bioorg Med Chem Lett· June 2016

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Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1.
Zacharia Cheruvallath, Mingnam Tang, Christopher McBride, Mallareddy Komandla, Joanne Miura, Darin Vanderpool

Bioorg Med Chem Lett· June 2016

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Residence time and kinetic efficiency analysis of extracellular signal-regulated kinase 2 inhibitors.
Darin Vanderpool, Charles E Grimshaw, J David Lawson, Jacques Ermolieff

Anal Biochem· March 2015

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Characterization of the CHK1 allosteric inhibitor binding site.
Darin Vanderpool, Ted O Johnson, Chen Ping, Simon Bergqvist, Gordon Alton

Biochemistry· October 2009

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Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands.
Raymond A Hudack, Nancy S Barta, Chuangxing Guo, Judith Deal, Liming Dong, Darin Vanderpool

J Med Chem· February 2006

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Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics.
Charles R Kissinger, Paul A Rejto, Laura A Pelletier, James A Thomson, Richard E Showalter, Darin Vanderpool

J Mol Biol· September 2004

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