Publications by authors named "Clint D J Tavares"

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Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation.
Amanda L Bohanon, Luke S Browning, Rae M Sammons, Andrea Piserchio, Clint D J Tavares

bioRxiv· July 2025

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A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Pedro Latorre-Muro, Katherine E O'Malley, Christopher F Bennett, Elizabeth A Perry, Eduardo Balsa, Clint D J Tavares

Cell Metab· March 2021

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Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action.
Clint D J Tavares, Stefan Aigner, Kfir Sharabi, Shashank Sathe, Beste Mutlu

Proc Natl Acad Sci U S A· September 2020

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Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency.
Chi Luo, Jiaxin Liang, Kfir Sharabi, Maximilian Hatting, Elizabeth A Perry, Clint D J Tavares

Cancer Res· August 2020

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Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo.
Tamer S Kaoud, William H Johnson, Nancy D Ebelt, Andrea Piserchio, Diana Zamora-Olivares, Clint D J Tavares

Nat Commun· November 2019

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Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives.
Kfir Sharabi, Clint D J Tavares, Pere Puigserver

Curr Diab Rep· September 2019

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Insulin regulation of gluconeogenesis.
Maximilian Hatting, Clint D J Tavares, Kfir Sharabi, Amy K Rines, Pere Puigserver

Ann N Y Acad Sci· January 2018

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Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth.
Jiney Jose, Clint D J Tavares, Nancy D Ebelt, Alessia Lodi, Ramakrishna Edupuganti

ACS Med Chem Lett· October 2017

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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.
Kfir Sharabi, Hua Lin, Clint D J Tavares, John E Dominy, Joao Paulo Camporez

Cell· March 2017

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Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION.
Clint D J Tavares, David H Giles, Gabriel Stancu, Catrina A Chitjian, Scarlett B Ferguson

J Biol Chem· February 2017

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Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.
Amy K Rines, Kfir Sharabi, Clint D J Tavares, Pere Puigserver

Nat Rev Drug Discov· November 2016

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Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.
Joeva J Barrow, Eduardo Balsa, Francisco Verdeguer, Clint D J Tavares, Meghan S Soustek

Mol Cell· October 2016

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Structural Basis for the Recognition of Eukaryotic Elongation Factor 2 Kinase by Calmodulin.
Kwangwoon Lee, Sébastien Alphonse, Andrea Piserchio, Clint D J Tavares, David H Giles

Structure· September 2016

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Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.
Clint D J Tavares, Ashwini K Devkota, Kevin N Dalby, Eun Jeong Cho

Methods Mol Biol· August 2016

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The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1α Transcriptional Coactivator.
Clint D J Tavares, Kfir Sharabi, John E Dominy, Yoonjin Lee, Marta Isasa

J Biol Chem· May 2016

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Molecular pathophysiology of hepatic glucose production.
Kfir Sharabi, Clint D J Tavares, Amy K Rines, Pere Puigserver

Mol Aspects Med· December 2015

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Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis.
Qiantao Wang, Ramakrishna Edupuganti, Clint D J Tavares, Kevin N Dalby, Pengyu Ren

Front Mol Biosci· May 2015

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Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.
Ramakrishna Edupuganti, Qiantao Wang, Clint D J Tavares, Catrina A Chitjian, James L Bachman

Bioorg Med Chem· September 2014

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The molecular mechanism of eukaryotic elongation factor 2 kinase activation.
Clint D J Tavares, Scarlett B Ferguson, David H Giles, Qiantao Wang, Rebecca M Wellmann

J Biol Chem· August 2014

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High-throughput screens for eEF-2 kinase.
Ashwini K Devkota, Mangalika Warthaka, Ramakrishna Edupuganti, Clint D J Tavares, William H Johnson

J Biomol Screen· March 2014

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Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer.
Ibrahim Tekedereli, S Neslihan Alpay, Clint D J Tavares, Zehra E Cobanoglu, Tamer S Kaoud

PLoS One· April 2013

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Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence.
Clint D J Tavares, John P O'Brien, Olga Abramczyk, Ashwini K Devkota, Kevin S Shores

Biochemistry· March 2012

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Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact.
Ashwini K Devkota, Clint D J Tavares, Mangalika Warthaka, Olga Abramczyk, Kyle D Marshall

Biochemistry· March 2012

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Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli.
Olga Abramczyk, Clint D J Tavares, Ashwini K Devkota, Alexey G Ryazanov, Benjamin E Turk

Protein Expr Purif· October 2011

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