Publications by authors named "Colette Dooley"

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Opioid Affinity of Diazacyclic Peptidomimetic Compounds Derived from Reduced Polyamides.
Prakash Chaudhari, Ashley Bunnell, Manivannan Yegambaram, Colette Dooley, Adel Nefzi

Int J Mol Sci· August 2025

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Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics.
Haylee R Hammond, Prakash Chaudhari, Ashley Bunnell, Khadija Nefzi, Chongguang Chen, Colette T Dooley

ACS Med Chem Lett· March 2025

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Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics.
Jay P McLaughlin, Ramanjaneyulu Rayala, Ashley J Bunnell, Mukund P Tantak, Shainnel O Eans, Colette T Dooley

Int J Mol Sci· August 2022

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Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.
Hannah M Harris, Shainnel O Eans, Michelle L Ganno, Jennifer C Davis, Colette T Dooley

Org Biomol Chem· June 2019

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Bridging immunogenetics and immunoproteomics: Model positional scanning library analysis for Major Histocompatibility Complex class II DQ in Tursiops truncatus.
Colette T Dooley, Tatiana Ferrer, Heidi Pagán, Gregory M O'Corry-Crowe

PLoS One· January 2019

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A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.
Jiaan Shao, Richard A Houghten, Colette T Dooley, Margret Cazares, Jay P McLaughlin

Org Biomol Chem· September 2017

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Altered secondary structure of Dynorphin A associates with loss of opioid signalling and NMDA-mediated excitotoxicity in SCA23.
Cleo J L M Smeets, Justyna Zmorzyńska, Manuel N Melo, Anita Stargardt, Colette Dooley

Hum Mol Genet· July 2016

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Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.
Yangmei Li, Margret Cazares, Jinhua Wu, Richard A Houghten, Laurence Toll, Colette Dooley

J Med Chem· February 2016

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Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.
Richard A Houghten, Michelle L Ganno, Jay P McLaughlin, Colette T Dooley, Shainnel O Eans

ACS Comb Sci· January 2016

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Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.
Shainnel O Eans, Michelle L Ganno, Elisa Mizrachi, Richard A Houghten, Colette T Dooley

J Med Chem· June 2015

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Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.
Miao Hu, Marc A Giulianotti, Jay P McLaughlin, Jiaan Shao, Ginamarie Debevec, Colette Dooley

Eur J Med Chem· March 2015

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Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin.
Saoussen Hammami, Zine Mighri, Colette T Dooley, Adel Nefzi

Bioorg Med Chem Lett· September 2014

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Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure.
Karina Martinez-Mayorga, Kendall G Byler, Austin B Yongye, Marc A Giulianotti, Colette T Dooley

Eur J Med Chem· August 2013

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Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.
Yangmei Li, Colette T Dooley, Jaime A Misler, Ginamarie Debevec, Marc A Giulianotti

ACS Comb Sci· December 2012

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A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.
Marc A Giulianotti, Ginamarie Debevec, Radleigh G Santos, Laura E Maida, Wenteng Chen, Colette T Dooley

ACS Comb Sci· September 2012

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Toxicity of 6-hydroxydopamine: live cell imaging of cytoplasmic redox flux.
Colette T Dooley, Ling Li, Jaime A Misler, Jane H Thompson

Cell Biol Toxicol· April 2012

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Integrating computational and mixture-based screening of combinatorial libraries.
Austin B Yongye, Clemencia Pinilla, Jose L Medina-Franco, Marc A Giulianotti, Colette T Dooley

J Mol Model· June 2011

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Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.
Radleigh G Santos, Marc A Giulianotti, Colette T Dooley, Clemencia Pinilla, Jon R Appel

ACS Comb Sci· May 2011

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Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.
Kate J Reilley, Marc Giulianotti, Colette T Dooley, Adel Nefzi, Jay P McLaughlin

AAPS J· September 2010

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Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.
Austin B Yongye, Jon R Appel, Marc A Giulianotti, Colette T Dooley, Jose L Medina-Franco

Bioorg Med Chem· August 2009

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The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.
Hiroshi Nagasaki, Shinjae Chung, Colette T Dooley, Zhiwei Wang, Chunying Li

Eur J Pharmacol· January 2009

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Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.
Karina Martínez-Mayorga, Jose L Medina-Franco, Marc A Giulianotti, Clemencia Pinilla, Colette T Dooley

Bioorg Med Chem· June 2008

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Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Richard A Houghten, Clemencia Pinilla, Marc A Giulianotti, Jon R Appel, Colette T Dooley

J Comb Chem· February 2008

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Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.
Adel Nefzi, John M Ostresh, Jon R Appel, Jean Bidlack, Colette T Dooley

Bioorg Med Chem Lett· August 2006

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In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.
Richard A Houghten, Colette T Dooley, Jon R Appel

AAPS J· May 2006

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