Publications by authors named "Colin Edge"

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Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors.
Jeffrey M Axten, Xiao Ding, Luigi Piero Stasi, Baowei Zhao, Yingxia Sang, Colin Edge

RSC Med Chem· November 2025

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Synthesis of 2,6--Tetrahydropyrans Using a Palladium-Catalyzed Oxidative Heck Redox-Relay Strategy.
Holly E Bonfield, Colin M Edge, Marc Reid, Alan R Kennedy, David D Pascoe

Org Lett· April 2024

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A Concise Enantioselective Synthesis of Fluorinated Pyrazolo-Piperidine GSK3901383A Enabled by an Organocatalytic Aza-Michael Addition.
Benedict Barron, Colin Edge, Sabine Fenner, Harry Shrives, Steven Sollis

Org Lett· March 2024

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Correction to: Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort.
Iain L Hutchison, Fran Ridout, Sharon M Y Cheung, Neil Shah, Peter Hardee, Colin Edge

Br J Cancer· March 2022

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Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort.
Iain L Hutchison, Fran Ridout, Sharon M Y Cheung, Neil Shah, Peter Hardee, Colin Edge

Br J Cancer· November 2019

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5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy.
Xiao Ding, Luigi Piero Stasi, Xuedong Dai, Kai Long, Cheng Peng, Colin Edge

Bioorg Med Chem Lett· January 2019

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Accelerating molecular discovery through data and physical sciences: Applications to peptide-membrane interactions.
Flaviu Cipcigan, Anna Paola Carrieri, Edward O Pyzer-Knapp, Ritesh Krishna, Ya-Wen Hsiao, Colin Edge

J Chem Phys· June 2018

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Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors.
Xiao Ding, Luigi Piero Stasi, Ming-Hsun Ho, Baowei Zhao, Hailong Wang, Colin Edge

Bioorg Med Chem Lett· May 2018

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A Perspective on Water Site Prediction Methods for Structure Based Drug Design.
Alan P Graves, Ian D Wall, Colin M Edge, James M Woolven, Guanglei Cui

Curr Top Med Chem· September 2017

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Discovery of 5-substituent-N-arylbenzamide derivatives as potent, selective and orally bioavailable LRRK2 inhibitors.
Xiao Ding, Xuedong Dai, Kai Long, Cheng Peng, Daniele Andreotti, Colin Edge

Bioorg Med Chem Lett· September 2017

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New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study.
Marie-Pierre Dréanic, Colin M Edge, Tell Tuttle

ACS Omega· September 2017

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Decorating Self-Assembled Peptide Cages with Proteins.
James F Ross, Angela Bridges, Jordan M Fletcher, Deborah Shoemark, Dominic Alibhai, Colin M Edge

ACS Nano· August 2017

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Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.
Ben Bax, Chun Wa Chung, Colin Edge

Acta Crystallogr D Struct Biol· February 2017

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Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.
Graeme W Carlile, Renaud Robert, Elizabeth Matthes, Qi Yang, Roberto Solari, Colin M Edge

Mol Pharmacol· August 2016

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A High-Throughput Screen to Identify LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease Using RapidFire Mass Spectrometry.
Melanie Leveridge, Lee Collier, Colin Edge, Phil Hardwicke, Bill Leavens

J Biomol Screen· February 2016

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Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.
Dianfan Li, Nicole Howe, Abhiram Dukkipati, Syed T A Shah, Benjamin D Bax, Colin Edge

Cryst Growth Des· April 2014

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Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry.
Melanie V Leveridge, Ana Isabel Bardera, William LaMarr, Andrew Billinton, Ben Bellenie, Colin Edge

J Biomol Screen· June 2012

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Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.
Xianfeng Li, Yong-Kang Zhang, Yang Liu, Charles Z Ding, Qun Li, Colin M Edge

Bioorg Med Chem Lett· June 2010

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Assessment of nonequilibrium free energy methods.
Benjamin P Cossins, Sebastien Foucher, Colin M Edge, Jonathan W Essex

J Phys Chem B· April 2009

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Protein-ligand binding affinity by nonequilibrium free energy methods.
Benjamin P Cossins, Sebastien Foucher, Colin M Edge, Jonathan W Essex

J Phys Chem B· November 2008

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Parametrization of Reversible Digitally Filtered Molecular Dynamics Simulations.
Adrian P Wiley, Martin T Swain, Stephen C Phillips, Jonathan W Essex, Colin M Edge

J Chem Theory Comput· January 2005

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Mutation of charged residues in the TR3 death domain does not perturb interaction with TRADD.
Elisabeth Tunbridge, Colin Dingwall, Colin Edge, Madhavi Konduri, Douglas J DeMarini

Protein Eng· October 2002

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