Publications by authors named "Colin Dingwall"

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Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.
Emma H Gray, Kurt J De Vos, Colin Dingwall, Michael S Perkinton, Christopher C J Miller

J Alzheimers Dis· January 2012

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Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.
Vasiliki Michaki, Francesc X Guix, Krist'l Vennekens, Sebastian Munck, Colin Dingwall

J Biol Chem· January 2012

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ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
Marcia L Moss, Gary Powell, Miles A Miller, Lori Edwards, Bin Qi, Colin Dingwall

J Biol Chem· November 2011

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Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP.
Mary Hughes, Vladimir Snetkov, Ruth-Sarah Rose, Sebastian Trousil, Jacqueline E Mermoud, Colin Dingwall

J Neurochem· August 2010

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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon

Bioorg Med Chem Lett· August 2010

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon

Bioorg Med Chem Lett· July 2009

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Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall

J Med Chem· June 2008

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BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Paul Beswick, Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall

Bioorg Med Chem Lett· February 2008

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Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Ishrut Hussain, Julie Hawkins, David Harrison, Christopher Hille, Gareth Wayne, Colin Dingwall

J Neurochem· February 2007

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Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease.
Hannu Koistinen, Rab Prinjha, Peter Soden, Alex Harper, Steven J Banner, Colin Dingwall

Muscle Nerve· October 2006

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gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.
Laura E Doglio, Ritu Kanwar, George R Jackson, Mar Perez, Jesús Avila, Colin Dingwall

Neuron· May 2006

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Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction.
Shanaka Thilakawardhana, David M Everett, Paul R Murdock, Colin Dingwall, James S Owen

Neurobiol Aging· June 2005

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BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.
Barbara Angeletti, Kevin J Waldron, Katie B Freeman, Hinayana Bawagan, Ishrut Hussain, Colin Dingwall

J Biol Chem· May 2005

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Neuronal membrane cholesterol loss enhances amyloid peptide generation.
Jose Abad-Rodriguez, Maria Dolores Ledesma, Katleen Craessaerts, Simona Perga, Miguel Medina, Colin Dingwall

J Cell Biol· December 2004

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p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
Steven Ackerley, Andrew J Grierson, Steven Banner, Michael S Perkinton, Janet Brownlees, Colin Dingwall

Mol Cell Neurosci· June 2004

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Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis.
Nadia Korfali, Sandrine Ruchaud, David Loegering, Delphine Bernard, Colin Dingwall

J Biol Chem· January 2004

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Raft disorganization leads to reduced plasmin activity in Alzheimer's disease brains.
Maria Dolores Ledesma, José Abad-Rodriguez, Cristian Galvan, Elisa Biondi, Pilar Navarro, Colin Dingwall

EMBO Rep· December 2003

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BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.
Steve M Harrison, Alex J Harper, Julie Hawkins, Graham Duddy, Evelyn Grau, Colin Dingwall

Mol Cell Neurosci· November 2003

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Characterization of the ectodomain shedding of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).
Ishrut Hussain, Julie Hawkins, Aarti Shikotra, David R Riddell, Andrew Faller, Colin Dingwall

J Biol Chem· September 2003

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Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein.
Joanna M Cordy, Ishrut Hussain, Colin Dingwall, Nigel M Hooper, Anthony J Turner

Proc Natl Acad Sci U S A· September 2003

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Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons.
Mary Vinson, Oliver Rausch, Peter R Maycox, Rab K Prinjha, Debra Chapman, Colin Dingwall

Mol Cell Neurosci· March 2003

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