Publications by authors named "Gareth Wayne"

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Recent advances in human respiratory epithelium models for drug discovery.
Naheem Yaqub, Gareth Wayne, Martin Birchall, Wenhui Song

Biotechnol Adv· March 2022

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Epithelial Barrier Integrity Profiling: Combined Approach Using Cellular Junctional Complex Imaging and Transepithelial Electrical Resistance.
Theresa J Pell, Mike B Gray, Sarah J Hopkins, Richard Kasprowicz, James D Porter, Gareth J Wayne

SLAS Discov· August 2021

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Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.
Radu Rapiteanu, Tina Karagyozova, Natalie Zimmermann, Kuljit Singh, Gareth Wayne

Eur Respir J· May 2020

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Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.
André Mateus, Laurie J Gordon, Gareth J Wayne, Helena Almqvist, Hanna Axelsson

Proc Natl Acad Sci U S A· July 2017

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Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability.
Laurie J Gordon, Morven Allen, Per Artursson, Michael M Hann, Bill J Leavens, Gareth J Wayne

J Biomol Screen· February 2016

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A phenotypic screening approach in cord blood-derived mast cells to identify anti-inflammatory compounds.
Rejbinder Kaur, Lisa A Sloan, Andy D Blanchard, Janet L Smith, Ian Churcher, Gareth J Wayne

J Biomol Screen· December 2013

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Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
Catherine M Alder, Martin Ambler, Amanda J Campbell, Aurelie C Champigny, Angela M Deakin, Gareth Wayne

ACS Med Chem Lett· October 2013

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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Gareth Wayne

Bioorg Med Chem Lett· August 2010

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Gareth Wayne

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Gareth Wayne

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Gareth Wayne

Bioorg Med Chem Lett· July 2009

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Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Gareth Wayne

J Med Chem· June 2008

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BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, Gareth Wayne

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, Gareth Wayne

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Paul Beswick, Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, Gareth Wayne

Bioorg Med Chem Lett· February 2008

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TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.
Gareth J Wayne, Su-Jun Deng, Augustin Amour, Satty Borman, Rosalie Matico

J Biol Chem· July 2007

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Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Ishrut Hussain, Julie Hawkins, David Harrison, Christopher Hille, Gareth Wayne

J Neurochem· February 2007

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A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates.
Daniel A Thomas, Peter Francis, Carla Smith, Steven Ratcliffe, Nicholas J Ede, Gareth Wayne

Proteomics· April 2006

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Continuous real-time measurement of tumor necrosis factor-alpha converting enzyme activity on live cells.
Montserrat Alvarez-Iglesias, Gareth Wayne, Kieran P O'Dea, Augustin Amour, Masao Takata

Lab Invest· November 2005

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Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.
Zoe Scholefield, Edwin A Yates, Gareth Wayne, Augustin Amour, William McDowell

J Cell Biol· October 2003

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5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
Marie E Migaud, Rupert C Wilmouth, Gary I Mills, Gareth J Wayne, Catherine Risley

Chem Commun (Camb)· June 2002

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