Publications by authors named "Colin Garvie"

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Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.
Subrata Shaw, Wei Jiang, Jason Rush, Nancy Dumont, John Kim, Colin W Garvie

iScience· March 2025

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Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform.
Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Colin W Garvie

bioRxiv· May 2024

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Identification of a new Corin atrial natriuretic peptide-converting enzyme substrate: Agouti-signaling protein (ASIP).
Bryan T MacDonald, Nadine H Elowe, Colin W Garvie, Virendar K Kaushik, Patrick T Ellinor

bioRxiv· April 2023

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Velcrin-induced selective cleavage of tRNA(TAA) by SLFN12 causes cancer cell death.
Sooncheol Lee, Stephanie Hoyt, Xiaoyun Wu, Colin Garvie, Joseph McGaunn

Nat Chem Biol· March 2023

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Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Peter G Miller, Murugappan Sathappa, Jamie A Moroco, Wei Jiang, Yue Qian, Colin W Garvie

Nat Commun· June 2022

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Rare, Damaging DNA Variants in and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.
Minxian Wang, Vivian S Lee-Kim, Deepak S Atri, Nadine H Elowe, John Yu, Colin W Garvie

Circ Genom Precis Med· October 2021

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Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Colin W Garvie, Xiaoyun Wu, Malvina Papanastasiou, Sooncheol Lee, James Fuller

Nat Commun· July 2021

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Assessing optimal: inequalities in codon optimization algorithms.
Matthew J Ranaghan, Jeffrey J Li, Dylan M Laprise, Colin W Garvie

BMC Biol· February 2021

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Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Xiaoyun Wu, Gavin R Schnitzler, Galen F Gao, Brett Diamond, Andrew R Baker, Colin W Garvie

J Biol Chem· November 2020

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Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Xiaoyun Wu, Gavin R Schnitzler, Galen F Gao, Brett Diamond, Andrew R Baker, Colin W Garvie

J Biol Chem· March 2020

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Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
Steven M Corsello, Rohith T Nagari, Ryan D Spangler, Jordan Rossen, Mustafa Kocak, Colin W Garvie

Nat Cancer· February 2020

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Development of a novel, sensitive cell-based corin assay.
Pascal Lambertz, Laura Theisen, Natalie Längst, Colin W Garvie, Bryan T MacDonald

Biochem Pharmacol· February 2019

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The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.
Matthew J Ranaghan, Michael A Durney, Michael F Mesleh, Patrick R McCarren, Colin W Garvie

Biochemistry· December 2017

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Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor.
Colin W Garvie, Cara V Fraley, Nadine H Elowe, Elizabeth K Culyba, Christopher T Lemke

Protein Sci· November 2016

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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein.
Marius S Pop, Nicolas Stransky, Colin W Garvie, Jean-Philippe Theurillat, Emily C Hartman

Mol Cancer Ther· June 2014

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Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain.
Colin W Garvie, Keshav Vasanthavada, Qing Xiang

Biochim Biophys Acta· August 2013

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Solution-based approach to study binding to the eIF4E cap-binding site using CD spectroscopy.
Colin W Garvie

Anal Biochem· March 2013

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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.
Bradford Graves, Thelma Thompson, Mingxuan Xia, Cheryl Janson, Christine Lukacs, Colin Garvie

Proc Natl Acad Sci U S A· July 2012

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Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.
Kholiswa M Laird, LaTese L Briggs, Jeremy M Boss, Michael F Summers, Colin W Garvie

J Mol Biol· October 2010

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Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5.
Daniel Fitzsimmons, Kara Lukin, Ryan Lutz, Colin W Garvie, Cynthia Wolberger

J Mol Biol· September 2009

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Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP.
LaTese Briggs, Kholiswa Laird, Jeremy M Boss, Colin W Garvie

Proteins· August 2009

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Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5.
Colin W Garvie, Jeremy M Boss

Biochim Biophys Acta· December 2008

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Characterization of the RFX complex and the RFX5(L66A) mutant: implications for the regulation of MHC class II gene expression.
Colin W Garvie, Jason R Stagno, Sarah Reid, Ashina Singh, Erik Harrington

Biochemistry· February 2007

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Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP).
Holly Maier, Rachel Ostraat, Sarah Parenti, Daniel Fitzsimmons, Lawrence J Abraham, Colin W Garvie

Nucleic Acids Res· October 2003

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Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships.
Colin W Garvie, Miles A Pufall, Barbara J Graves, Cynthia Wolberger

J Biol Chem· November 2002

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