Publications by authors named "Colin Hutton"

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Phenoscaping Reveals Multimodal γδ T-cell Cytotoxicity as a Strategy to Overcome Cancer Cell-Mediated Immunomodulation.
Callum Baird Nattress, Rhianna O'Sullivan, Daniel Fowler, Colin Hutton, Petra Vlckova

Cancer Res· November 2025

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A mini-colon models colon cancer and its microenvironment.
Colin Hutton, Vivian S W Li

Nat Biotechnol· May 2025

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USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
Laura Novellasdemunt, Anna Kucharska, Anna Baulies, Colin Hutton, Georgios Vlachogiannis

Stem Cell Reports· February 2023

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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids.
Christopher R Below, Joanna Kelly, Alexander Brown, Jonathan D Humphries, Colin Hutton

Nat Mater· January 2022

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Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
Brian Y Lee, Elizabeth K J Hogg, Christopher R Below, Alexander Kononov, Adrian Blanco-Gomez, Colin Hutton

Nat Commun· December 2021

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Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy.
Victoria S Pelly, Agrin Moeini, Lisanne M Roelofsen, Eduardo Bonavita, Charlotte R Bell, Colin Hutton

Cancer Discov· October 2021

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Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
Colin Hutton, Felix Heider, Adrian Blanco-Gomez, Antonia Banyard, Alexander Kononov

Cancer Cell· September 2021

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Ben Acton, Helen F Small, Kate M Smith, Alison McGonagle, Alexandra I J Stowell, Colin P Hutton

Bioorg Med Chem Lett· February 2019

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
Bohdan Waszkowycz, Kate M Smith, Alison E McGonagle, Allan M Jordan, Ben Acton, Colin P Hutton

J Med Chem· December 2018

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
Dominic I James, Kate M Smith, Allan M Jordan, Emma E Fairweather, Louise A Griffiths, Colin P Hutton

ACS Chem Biol· November 2016

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