Publications by authors named "Colin J Jackson"

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Expanding the biocatalytic and oxidative landscape of the old yellow enzyme family.
David W White, Rebecca L Frkic, Samantha Iamurri, Parisa Keshavarz-Joud, Tamra Blue, Colin J Jackson

Protein Sci· November 2025

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Entropy, enthalpy, and evolution: Adaptive trade-offs in protein binding thermodynamics.
Rosemary Georgelin, Colin J Jackson

Curr Opin Struct Biol· October 2025

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A F-dependent Single Domain Chemogenetic Tool for Protein De-dimerization.
James Antoney, Stephanie Kainrath, Joshua G Dubowsky, F Hafna Ahmed, Suk Woo Kang, Colin J Jackson

J Mol Biol· September 2025

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Protein evolution as a complex system.
Barnabas Gall, Sacha B Pulsford, Dana S Matthews, Matthew A Spence, Joe A Kaczmarski, Colin J Jackson

Nat Chem Biol· September 2025

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Synthesis, screening and validation of cysteine-reactive fragments as chikungunya virus protease inhibitors.
Junming He, Henry Illingworth, Sven Ullrich, Pritha Ghosh, Jennifer Ton, Colin J Jackson

Bioorg Med Chem Lett· July 2025

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A Thermostable Bacterial Metallohydrolase that Degrades Organophosphate Plasticizers.
Dawei Ji, Rebecca L Frkic, Javad Delyami, Joachim S Larsen, Matthew A Spence, Colin J Jackson

Chembiochem· June 2025

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Exploring Large Protein Sequence Space through Homology- and Representation-based Hierarchical Clustering.
John Z Chen, Barnabas Gall, Sacha B Pulsford, Nobuhiko Tokuriki, Colin J Jackson

Mol Biol Evol· June 2025

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Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape.
Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee, Colin J Jackson

Sci Adv· May 2025

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Having your cake and eating it too - a new target for sporozoite-neutralising mAbs.
Joe A Kaczmarski, Colin J Jackson, Ian A Cockburn

Trends Parasitol· April 2025

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Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains.
Mahakaran Sandhu, John Z Chen, Dana S Matthews, Matthew A Spence, Sacha B Pulsford, Colin J Jackson

Biochemistry· April 2025

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An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function.
Maltesh Kambali, Yan Li, Petr Unichenko, Jessica A Feria Pliego, Rachita Yadav, Colin J Jackson

Mol Psychiatry· March 2025

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Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4-Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites.
Haocheng Qianzhu, Elwy H Abdelkader, Adarshi P Welegedara, Edan Habel, Nathan Paul, Colin J Jackson

Angew Chem Int Ed Engl· March 2025

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Isolation, identification, and characterisation of the malachite green detoxifying bacterial strain Bacillus pacificus ROC1 and the azoreductase AzrC.
Shanza Bibi, Callum W Breeze, Vusqa Jadoon, Anum Fareed, Alina Syed, Colin J Jackson

Sci Rep· January 2025

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Partitioning of an Enzyme-Polymer Surfactant Nanocomplex into Lipid-Rich Cellular Compartments Drives In Situ Hydrolysis of Organophosphates.
Benjamin M Carter, Graham J Day, William H Zhang, Richard B Sessions, Colin J Jackson

Small· November 2024

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The ultra-high affinity transport proteins of ubiquitous marine bacteria.
Ben E Clifton, Uria Alcolombri, Gen-Ichiro Uechi, Colin J Jackson, Paola Laurino

Nature· October 2024

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1.3 Å Crystal Structure of Peptidyl-Prolyl Isomerase B with Uniform Substitution of Valine by (2,3)-4-Fluorovaline Reveals Structure Conservation and Multiple Staggered Rotamers of CHF Groups.
Rebecca L Frkic, Yi Jiun Tan, Ansis Maleckis, Nicholas F Chilton, Gottfried Otting, Colin J Jackson

Biochemistry· October 2024

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Exploiting Hydrophobic Amino Acid Scanning to Develop Cyclic Peptide Inhibitors of the SARS-CoV-2 Main Protease with Antiviral Activity.
Katriona Harrison, Patrick W Carlos, Sven Ullrich, Anupriya Aggarwal, Jason Johansen-Leete, Colin J Jackson

Chemistry· August 2024

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Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design.
Jake W Saunders, Adam M Damry, Vanessa Vongsouthi, Matthew A Spence, Rebecca L Frkic, Colin J Jackson

Biochemistry· July 2024

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Conformational Preferences of the Non-Canonical Amino Acids (2,4)-5-Fluoroleucine, (2,4)-5-Fluoroleucine, and 5,5'-Difluoroleucine in a Protein.
Rebecca L Frkic, Yi Jiun Tan, Elwy H Abdelkader, Ansis Maleckis, Eliza Tarcoveanu, Colin J Jackson

Biochemistry· June 2024

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Identification and Characterization of a Bacterial Periplasmic Solute Binding Protein That Binds l-Amino Acid Amides.
Oliver B Smith, Rebecca L Frkic, Marina G Rahman, Colin J Jackson, Joe A Kaczmarski

Biochemistry· May 2024

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Cyanobacterial α-carboxysome carbonic anhydrase is allosterically regulated by the Rubisco substrate RuBP.
Sacha B Pulsford, Megan A Outram, Britta Förster, Timothy Rhodes, Simon J Williams, Colin J Jackson

Sci Adv· May 2024

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Mononuclear binding and catalytic activity of europium(III) and gadolinium(III) at the active site of the model metalloenzyme phosphotriesterase.
Callum W Breeze, Yuji Nakano, Eleanor C Campbell, Rebecca L Frkic, David W Lupton, Colin J Jackson

Acta Crystallogr D Struct Biol· April 2024

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Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors.
Anthony T Meger, Matthew A Spence, Mahakaran Sandhu, Dana Matthews, Jackie Chen, Colin J Jackson

Cell Syst· April 2024

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An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides.
Maxine Treisman, Laura Coe, Yongwei Zhao, Vishnu Mini Sasi, Jemma Gullick, Colin J Jackson

Org Lett· March 2024

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Improving plastic degrading enzymes via directed evolution.
Yvonne Joho, Vanessa Vongsouthi, Chloe Gomez, Joachim S Larsen, Albert Ardevol, Colin J Jackson

Protein Eng Des Sel· January 2024

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