Publications by authors named "Jake Saunders"

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Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape.
Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee

Sci Adv· May 2025

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Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design.
Jake W Saunders, Adam M Damry, Vanessa Vongsouthi, Matthew A Spence, Rebecca L Frkic

Biochemistry· July 2024

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Ancestral sequence reconstruction for protein engineers.
Matthew A Spence, Joe A Kaczmarski, Jake W Saunders, Colin J Jackson

Curr Opin Struct Biol· August 2021

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An image-based Pathogen Box screen identifies new compounds with anti-Giardia activity and highlights the importance of assay choice in phenotypic drug discovery.
Snigdha Tiash, Jake Saunders, Christopher J S Hart, John H Ryan, Andrew G Riches

Int J Parasitol Drugs Drug Resist· April 2020

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The evolution of multiple active site configurations in a designed enzyme.
Nan-Sook Hong, Dušan Petrović, Richmond Lee, Ganna Gryn'ova, Miha Purg, Jake Saunders

Nat Commun· September 2018

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Enzyme characteristics of pathogen-specific trehalose-6-phosphate phosphatases.
Megan Cross, Siji Rajan, Janine Chekaiban, Jake Saunders, Chloe Hamilton

Sci Rep· May 2017

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