Publications by authors named "Colin K Skepper"

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Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
Guillaume Lapointe, Colin K Skepper, Lauren M Holder, Duncan Armstrong, Cornelia Bellamacina

J Med Chem· May 2021

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Synchronous bond molecular dynamics of conjugated chlorocyclopropyl alk-yn-enes revealed by ECD and UV-vis.
Colin K Skepper, Tadeusz F Molinski

Chirality· August 2020

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Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
Colin K Skepper, Duncan Armstrong, Carl J Balibar, Daniel Bauer, Cornelia Bellamacina

J Med Chem· July 2020

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Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.
Robert J Moreau, Colin K Skepper, Brent A Appleton, Anke Blechschmidt, Carl J Balibar

J Med Chem· April 2018

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Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity.
Colin K Skepper, Robert J Moreau, Brent A Appleton, Bret M Benton, Joseph E Drumm

J Med Chem· April 2018

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Optimization of CoaD Inhibitors against Gram-Negative Organisms through Targeted Metabolomics.
Christopher M Rath, Bret M Benton, Javier de Vicente, Joseph E Drumm, Mei Geng, Colin K Skepper

ACS Infect Dis· March 2018

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Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.
Shouliang Yang, Kuppusamy Sankar, Colin K Skepper, Timothy J Barker, John C Lukesh

Chem Sci· February 2017

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Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.
Erica L Campbell, Colin K Skepper, Kuppusamy Sankar, Katharine K Duncan, Dale L Boger

Org Lett· October 2013

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Total synthesis of enigmazole A from Cinachyrella enigmatica. Bidirectional bond constructions with an ambident 2,4-disubstituted oxazole synthon.
Colin K Skepper, Tim Quach, Tadeusz F Molinski

J Am Chem Soc· August 2010

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Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
Colin K Skepper, Doralyn S Dalisay, Tadeusz F Molinski

Bioorg Med Chem Lett· March 2010

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A tetrachloro polyketide hexahydro-1H-isoindolone, muironolide A, from the marine sponge Phorbas sp. natural products at the nanomole scale.
Doralyn S Dalisay, Brandon I Morinaka, Colin K Skepper, Tadeusz F Molinski

J Am Chem Soc· June 2009

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Synthesis and antifungal activity of (-)-(Z)-dysidazirine.
Colin K Skepper, Doralyn S Dalisay, Tadeusz F Molinski

Org Lett· November 2008

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Phorbasides A-E, cytotoxic chlorocyclopropane macrolide glycosides from the marine sponge Phorbas sp. CD determination of C-methyl sugar configurations.
John B MacMillan, Guang Xiong-Zhou, Colin K Skepper, Tadeusz F Molinski

J Org Chem· May 2008

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Long-chain 2H-azirines with heterogeneous terminal halogenation from the marine sponge Dysidea fragilis.
Colin K Skepper, Tadeusz F Molinski

J Org Chem· April 2008

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Rhizochalins C and D from the sponge Rhizochalina incrustata. A rare threo-sphingolipid and a facile method for determination of the carbonyl position in alpha,omega-bifunctionalized ketosphingolipids.
Tatyana N Makarieva, Pavel S Dmitrenok, Alexander M Zakharenko, Vladimir A Denisenko, Alla G Guzii, Colin K Skepper

J Nat Prod· December 2007

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Ene-yne tetrahydrofurans from the sponge Xestospongia muta. exploiting a weak CD effect for assignment of configuration.
Brandon I Morinaka, Colin K Skepper, Tadeusz F Molinski

Org Lett· May 2007

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Chlorocyclopropane macrolides from the marine sponge Phorbas sp. assignment of the configurations of phorbasides A and B by quantitative CD.
Colin K Skepper, John B Macmillan, Guang-Xiong Zhou, Makoto N Masuno, Tadeusz F Molinski

J Am Chem Soc· April 2007

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Addition of Cl2C: to (-)-O-menthyl acrylate under sonication-phase-transfer catalysis. Efficient synthesis of (+)- and (-)-(2-chlorocyclopropyl)methanol.
Makoto N Masuno, Douglas M Young, Alexander C Hoepker, Colin K Skepper, Tadeusz F Molinski

J Org Chem· May 2005

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