Publications by authors named "Tim Quach"

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Optimizing Triglyceride Prodrugs of a Model Immunomodulator: Conjugation through the Phenol of Mycophenolic Acid (MPA) Markedly Promotes Lymphatic Drug Transport.
Luojuan Hu, Tim Quach, Dan Zheng, Nathania J Leong, Garima Sharma

Mol Pharm· March 2025

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Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid.
Sifei Han, Tim Quach, Luojuan Hu, Shea Fern Lim, Dan Zheng

Mol Pharm· May 2023

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Corrigendum: Triglyceride-mimetic prodrugs of buprenorphine enhance oral bioavailability via promotion of lymphatic transport.
Tim Quach, Luojuan Hu, Sifei Han, Shea F Lim, Danielle Senyschyn

Front Pharmacol· September 2022

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Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport.
Tim Quach, Luojuan Hu, Sifei Han, Shea F Lim, Danielle Senyschyn

Front Pharmacol· April 2022

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Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles.
Sifei Han, Lianghe Mei, Tim Quach, Chris Porter, Natalie Trevaskis

Pharm Res· September 2021

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Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity.
Enyuan Cao, Matthew J Watt, Cameron J Nowell, Tim Quach, Jamie S Simpson

Nat Metab· September 2021

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A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.
Quynh N Mai, Priyank Shenoy, Tim Quach, Jeffri S Retamal, Arisbel B Gondin

J Biol Chem· August 2021

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Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice.
Ruby Kochappan, Enyuan Cao, Sifei Han, Luojuan Hu, Tim Quach

J Control Release· April 2021

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The Impact of Conjugation Position and Linker Chemistry on the Lymphatic Transport of a Series of Glyceride and Phospholipid Mimetic Prodrugs.
Sifei Han, Tim Quach, Luojuan Hu, Shea Fern Lim, Gracia Gracia

J Pharm Sci· January 2021

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Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.
Eunice E To, Ross Vlahos, Raymond Luong, Michelle L Halls, Patrick C Reading, Tim Quach

Nat Commun· July 2017

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Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.
Dane D Jensen, TinaMarie Lieu, Michelle L Halls, Nicholas A Veldhuis, Wendy L Imlach, Tim Quach

Sci Transl Med· May 2017

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Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.
Sifei Han, Luojuan Hu, Gracia, Tim Quach, Jamie S Simpson

Mol Pharm· October 2016

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Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.
Luojuan Hu, Tim Quach, Sifei Han, Shea F Lim, Preeti Yadav

Angew Chem Int Ed Engl· October 2016

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Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug.
Sifei Han, Luojuan Hu, Tim Quach, Jamie S Simpson, Natalie L Trevaskis

J Pharm Sci· February 2016

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Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug.
Sifei Han, Luojuan Hu, Tim Quach, Jamie S Simpson, Natalie L Trevaskis

Pharm Res· May 2015

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Galanin-3 receptor antagonism by SNAP 37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats.
Belinda L Ash, Tim Quach, Spencer J Williams, Andrew J Lawrence, Elvan Djouma

J Pharmacol Sci· February 2015

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Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies.
Sifei Han, Tim Quach, Luojuan Hu, Anisa Wahab, William N Charman

J Control Release· March 2014

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Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation.
Yan Yan Yeap, Natalie L Trevaskis, Tim Quach, Patrick Tso, William N Charman

Mol Pharm· May 2013

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Localization of oleuropeyl glucose esters and a flavanone to secretory cavities of Myrtaceae.
Allison M Heskes, Jason Q D Goodger, Sammi Tsegay, Tim Quach, Spencer J Williams

PLoS One· April 2013

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Total synthesis of the proposed structure of 8-deshydroxyajudazol A: a modified approach to 2,4-disubstituted oxazoles.
Stephen Birkett, Danny Ganame, Bill C Hawkins, Sébastien Meiries, Tim Quach

J Org Chem· January 2013

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Copper(I)-catalyzed cycloaddition of silver acetylides and azides: incorporation of volatile acetylenes into the triazole core.
Ilaria Proietti Silvestri, Fikre Andemarian, George N Khairallah, Su Wan Yap, Tim Quach

Org Biomol Chem· September 2011

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Total synthesis of 8-deshydroxyajudazol B.
Stephen Birkett, Danny Ganame, Bill C Hawkins, Sébastien Meiries, Tim Quach

Org Lett· April 2011

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Total synthesis of enigmazole A from Cinachyrella enigmatica. Bidirectional bond constructions with an ambident 2,4-disubstituted oxazole synthon.
Colin K Skepper, Tim Quach, Tadeusz F Molinski

J Am Chem Soc· August 2010

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Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association.
Doralyn S Dalisay, Tim Quach, Tadeusz F Molinski

Org Lett· April 2010

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Oxazoline-oxazinone oxidative rearrangement. divergent syntheses of (2S,3S)-4,4,4-trifluorovaline and (2S,4S)-5,5,5-Trifluoroleucine.
Julie A Pigza, Tim Quach, Tadeusz F Molinski

J Org Chem· August 2009

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