Publications by authors named "Colin W Ward"

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Is it time to retire the genus Rymovirus from the family Potyviridae?
Colin W Ward

Arch Virol· July 2017

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Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
Callum F Lawrence, Mai B Margetts, John G Menting, Nicholas A Smith, Brian J Smith, Colin W Ward

J Biol Chem· July 2016

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Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Tristan I Croll, Brian J Smith, Mai B Margetts, Jonathan Whittaker, Michael A Weiss, Colin W Ward

Structure· March 2016

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Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors.
John G Menting, Callum F Lawrence, Geoffrey K-W Kong, Mai B Margetts, Colin W Ward

Structure· July 2015

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Protective hinge in insulin opens to enable its receptor engagement.
John G Menting, Yanwu Yang, Shu Jin Chan, Nelson B Phillips, Brian J Smith, Colin W Ward

Proc Natl Acad Sci U S A· August 2014

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Vale Neil McKern - Australian Insulin Receptor Scientist.
Colin Wesley Ward, Michael Colin Lawrence

Front Endocrinol (Lausanne)· July 2014

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The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation.
Colin W Ward, John G Menting, Michael C Lawrence

Bioessays· November 2013

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How insulin engages its primary binding site on the insulin receptor.
John G Menting, Jonathan Whittaker, Mai B Margetts, Linda J Whittaker, Geoffrey K-W Kong, Colin W Ward

Nature· January 2013

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A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation.
Eva J Koziolek, Jacqueline F Donoghue, John D Bentley, George Lovrecz, Olan Dolezal, Colin W Ward

Growth Factors· October 2012

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Landmarks in insulin research.
Colin W Ward, Michael C Lawrence

Front Endocrinol (Lausanne)· August 2012

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Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families.
Colin W Ward, Michael C Lawrence

Curr Opin Struct Biol· June 2012

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Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.
Brian J Smith, Kun Huang, Geoffrey Kong, Shu Jin Chan, Satoe Nakagawa, Colin W Ward

Proc Natl Acad Sci U S A· April 2010

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Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.
Andrew E Whitten, Brian J Smith, John G Menting, Mai B Margetts, Neil M McKern, Colin W Ward

J Mol Biol· December 2009

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A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo.
Timothy E Adams, Eva J Koziolek, Peter H Hoyne, John D Bentley, Louis Lu, Colin W Ward

Growth Factors· June 2009

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A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.
John G Menting, Colin W Ward, Mai B Margetts, Michael C Lawrence

Biochemistry· June 2009

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Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor.
Colin W Ward, Michael C Lawrence

Bioessays· April 2009

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N-linked glycans of the human insulin receptor and their distribution over the crystal structure.
Lindsay G Sparrow, Michael C Lawrence, Jeffrey J Gorman, Phillip M Strike, Christine P Robinson, Colin W Ward

Proteins· April 2008

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Insulin receptor structure and its implications for the IGF-1 receptor.
Michael C Lawrence, Neil M McKern, Colin W Ward

Curr Opin Struct Biol· December 2007

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A designed ankyrin repeat protein evolved to picomolar affinity to Her2.
Christian Zahnd, Emanuel Wyler, Jochen M Schwenk, Daniel Steiner, Michael C Lawrence, Colin W Ward

J Mol Biol· June 2007

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The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.
Colin W Ward, Michael C Lawrence, Victor A Streltsov, Timothy E Adams, Neil M McKern

Trends Biochem Sci· March 2007

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The location and characterisation of the O-linked glycans of the human insulin receptor.
Lindsay G Sparrow, Jeffrey J Gorman, Phillip M Strike, Christine P Robinson, Neil M McKern, Colin W Ward

Proteins· February 2007

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A purine analog kinase inhibitor, calcium/calmodulin-dependent protein kinase II inhibitor 59, reveals a role for calcium/calmodulin-dependent protein kinase II in insulin-stimulated glucose transport.
Nicky Konstantopoulos, Seb Marcuccio, Stella Kyi, Violet Stoichevska, Laura A Castelli, Colin W Ward

Endocrinology· January 2007

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Structure of the insulin receptor ectodomain reveals a folded-over conformation.
Neil M McKern, Michael C Lawrence, Victor A Streltsov, Mei-Zhen Lou, Timothy E Adams, Colin W Ward

Nature· September 2006

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Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor.
V Chandana Epa, Colin W Ward

Protein Eng Des Sel· August 2006

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The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
Meizhen Lou, Thomas P J Garrett, Neil M McKern, Peter A Hoyne, V Chandana Epa, Colin W Ward

Proc Natl Acad Sci U S A· August 2006

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