Publications by authors named "Nelson B Phillips"

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Stabilization of a protein by a single halogen-based aromatic amplifier.
Krystel El Hage, Balamurugan Dhayalan, Yen-Shan Chen, Nelson B Phillips, Jonathan Whittaker, Manijeh H Phillips

Protein Sci· March 2025

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Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation.
Balamurugan Dhayalan, Michael D Glidden, Alexander N Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B Phillips

Front Endocrinol (Lausanne)· April 2022

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Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone-receptor activation.
Yen-Shan Chen, Jeremy Gleaton, Yanwu Yang, Balamurugan Dhayalan, Nelson B Phillips

Proc Natl Acad Sci U S A· July 2021

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Evolution of insulin at the edge of foldability and its medical implications.
Nischay K Rege, Ming Liu, Yanwu Yang, Balamurugan Dhayalan, Nalinda P Wickramasinghe, Nelson B Phillips

Proc Natl Acad Sci U S A· November 2020

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Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights the Distinction between External and Internal Diselenide Bridges.
Balamurugan Dhayalan, Yen-Shan Chen, Nelson B Phillips, Mamuni Swain, Nischay K Rege

Chemistry· April 2020

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Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding.
Michael D Glidden, Yanwu Yang, Nicholas A Smith, Nelson B Phillips, Kelley Carr

J Biol Chem· January 2018

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An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
Michael D Glidden, Khadijah Aldabbagh, Nelson B Phillips, Kelley Carr, Yen-Shan Chen, Manijeh Phillips

J Biol Chem· January 2018

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Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
Krystel El Hage, Vijay Pandyarajan, Nelson B Phillips, Brian J Smith, John G Menting

J Biol Chem· December 2016

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Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR.
Joseph D Racca, Yen-Shan Chen, Yanwu Yang, Nelson B Phillips, Michael A Weiss

J Biol Chem· October 2016

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Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.
Vijay Pandyarajan, Nelson B Phillips, Nischay Rege, Michael C Lawrence, Jonathan Whittaker

J Biol Chem· June 2016

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Aromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.
Vijay Pandyarajan, Brian J Smith, Nelson B Phillips, Linda Whittaker, Gabriella P Cox

J Biol Chem· December 2014

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Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box.
Joseph D Racca, Yen-Shan Chen, James D Maloy, Nalinda Wickramasinghe, Nelson B Phillips

J Biol Chem· November 2014

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Biophysical optimization of a therapeutic protein by nonstandard mutagenesis: studies of an iodo-insulin derivative.
Vijay Pandyarajan, Nelson B Phillips, Gabriela P Cox, Yanwu Yang, Jonathan Whittaker

J Biol Chem· August 2014

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Protective hinge in insulin opens to enable its receptor engagement.
John G Menting, Yanwu Yang, Shu Jin Chan, Nelson B Phillips, Brian J Smith

Proc Natl Acad Sci U S A· August 2014

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Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold.
Yen-Shan Chen, Joseph D Racca, Nelson B Phillips, Michael A Weiss

Proc Natl Acad Sci U S A· September 2013

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Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty.
Yen-Shan Chen, Joseph D Racca, Paul W Sequeira, Nelson B Phillips, Michael A Weiss

Proc Natl Acad Sci U S A· August 2013

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Fully convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography.
Michal Avital-Shmilovici, Kalyaneswar Mandal, Zachary P Gates, Nelson B Phillips, Michael A Weiss

J Am Chem Soc· February 2013

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α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.
Jonathan Whittaker, Linda J Whittaker, Charles T Roberts, Nelson B Phillips, Faramarz Ismail-Beigi

Proc Natl Acad Sci U S A· July 2012

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Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir.
Nelson B Phillips, Jonathan Whittaker, Faramarz Ismail-Beigi, Michael A Weiss

J Diabetes Sci Technol· March 2012

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Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex.
Nelson B Phillips, Joseph Racca, Yen-Shan Chen, Rupinder Singh, Agnes Jancso-Radek

J Biol Chem· October 2011

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An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design.
Yanwu Yang, Aneta Petkova, Kun Huang, Bin Xu, Qing-Xin Hua, Nelson B Phillips

J Biol Chem· April 2010

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Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
Nelson B Phillips, Zhu-li Wan, Linda Whittaker, Shi-Quan Hu, Kun Huang

J Biol Chem· April 2010

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Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.
Youhei Sohma, Qing-xin Hua, Ming Liu, Nelson B Phillips, Shi-Quan Hu

J Biol Chem· February 2010

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Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
Ming Zhao, Zhu-li Wan, Linda Whittaker, Bin Xu, Nelson B Phillips

J Biol Chem· November 2009

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Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
Qing-xin Hua, Satoe H Nakagawa, Wenhua Jia, Kun Huang, Nelson B Phillips

J Biol Chem· May 2008

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