Publications by authors named "Colm O'Brien"

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MicroRNA-29b targets ADAM12 and 19 to regulate the extracellular matrix in lamina cribrosa cells.
Aoife Smyth, Breedge Callaghan, Mustapha Irnaten, Darrell Andrews, Colin E Willoughby, Colm O'Brien

Cell Tissue Res· November 2025

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The Pleiotropic Effect of ANRIL in Glaucoma and Cardiovascular Disease.
Luke O'Brien, Daire J Hurley, Michael O'Leary, Liam Bourke, Colm O'Brien

Biomedicines· July 2025

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Fibrosis and Src Signalling in Glaucoma: From Molecular Pathways to Therapeutic Prospects.
Liam Bourke, Colm O'Brien

Int J Mol Sci· January 2025

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p53 and the E3 Ubiquitin Ligase MDM2 in Glaucomatous Lamina Cribrosa Cells.
Kealan McElhinney, Mustapha Irnaten, Jeffrey O'Callaghan, Colm O'Brien

Int J Mol Sci· November 2024

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The Role of αvβ3 Integrin in Lamina Cribrosa Cell Mechanotransduction in Glaucoma.
Mustapha Irnaten, Ellen Gaynor, Colm O'Brien

Cells· September 2024

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AAV-NDI1 Therapy Provides Significant Benefit to Murine and Cellular Models of Glaucoma.
Sophia Millington-Ward, Arpad Palfi, Ciara Shortall, Laura K Finnegan, Ethan Bargroff

Int J Mol Sci· August 2024

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Ability to Process Multisensory Information Is Impaired in Open Angle Glaucoma.
Ekaterina Loskutova, John S Butler, Annalisa Setti, Colm O'Brien, James Loughman

J Glaucoma· February 2024

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The annual conference of the Irish College of Ophthalmologists: examining over a decade of trends.
Lily Farrell, Khadija Gull, Siobhan Kelly, Colm O'Brien, Louise O'Toole

Ir J Med Sci· August 2023

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p53 and Myofibroblast Apoptosis in Organ Fibrosis.
Kealan McElhinney, Mustapha Irnaten, Colm O'Brien

Int J Mol Sci· April 2023

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Role of Epithelial-to-Mesenchymal Transition of Retinal Pigment Epithelial Cells in Glaucoma Cupping.
Eabha O'Driscoll, Emily Hughes, Mustapha Irnaten, Markus Kuehn, Deborah Wallace, Colm O'Brien

J Clin Med· April 2023

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Glaucoma - 'A Stiff Eye in a Stiff Body'.
Sarah Powell, Mustapha Irnaten, Colm O'Brien

Curr Eye Res· February 2023

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Calcium-Signalling in Human Glaucoma Lamina Cribrosa Myofibroblasts.
Mustapha Irnaten, Colm J O'Brien

Int J Mol Sci· January 2023

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Audit of outcomes following attendance at the City West drive-through IOP glaucoma clinic during the COVID-19 pandemic.
Sarah Powell, Emer Doolan, Karen Curtin, Aoife Doyle, Colm O'Brien

Ir J Med Sci· December 2022

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The Role of miR-29 Family in TGF-β Driven Fibrosis in Glaucomatous Optic Neuropathy.
Aoife Smyth, Breedge Callaghan, Colin E Willoughby, Colm O'Brien

Int J Mol Sci· September 2022

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Corneal Hysteresis, Intraocular Pressure, and Progression of Glaucoma: Time for a "Hyst-Oric" Change in Clinical Practice?
Patrick Murtagh, Colm O'Brien

J Clin Med· May 2022

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The Intertwined Roles of Oxidative Stress and Endoplasmic Reticulum Stress in Glaucoma.
Daire John Hurley, Caoimhe Normile, Mustapha Irnaten, Colm O'Brien

Antioxidants (Basel)· April 2022

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Matrix Mechanotransduction via Yes-Associated Protein in Human Lamina Cribrosa Cells in Glaucoma.
Rory Murphy, Mustapha Irnaten, Alan Hopkins, Jeffrey O'Callaghan, W Daniel Stamer, Colm J O'Brien

Invest Ophthalmol Vis Sci· January 2022

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Macular Pigment Response to Lutein, Zeaxanthin, and Meso-zeaxanthin Supplementation in Open-Angle Glaucoma: A Randomized Controlled Trial.
James Loughman, Ekaterina Loskutova, John S Butler, We Fong Siah, Colm O'Brien

Ophthalmol Sci· September 2021

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Metformin and Glaucoma-Review of Anti-Fibrotic Processes and Bioenergetics.
Daire J Hurley, Mustapha Irnaten, Colm O'Brien

Cells· August 2021

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Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma.
Ruth A Kelly, Kristin M Perkumas, Matthew Campbell, G Jane Farrar, W Daniel Stamer, Colm J O'Brien

Int J Mol Sci· August 2021

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The lysophosphatidic acid axis in fibrosis: Implications for glaucoma.
Amy O'Regan, Colm J O'Brien, Sarah B Eivers

Wound Repair Regen· July 2021

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Abnormal corneal properties in osteogenesis imperfecta and glaucoma: a case series.
Emer Doolan, Colm O'Brien

BMJ Open Ophthalmol· April 2021

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siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.
Paul S Cassidy, Ruth A Kelly, Ester Reina-Torres, Joseph M Sherwood, Marian M Humphries, Colm O'Brien

Mol Ther Methods Clin Dev· March 2021

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Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation.
Alison G Greene, Sarah B Eivers, Fiona McDonnell, Edward W J Dervan, Colm J O'Brien

Exp Eye Res· December 2020

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Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma.
Mustapha Irnaten, Aisling Duff, Abbot Clark, Colm O'Brien

J Clin Med· December 2020

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