Publications by authors named "Colm Ryan"

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Reduced PRC2 function causes asparaginase resistance in T-ALL by decreasing WNT pathway activity.
Thomas Lefeivre, Theodora-Ioana Grosu, Cosmin Tudose, Luke Jones, Theresa Elizabeth Leon, Colm J Ryan

Blood Adv· December 2025

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Response to Nutrient Stress in the Industrial Model Bacterium Cupriavidus necator: A Thermal Proteome Profiling (TPP) Investigation.
Kate McKeever, Jia-Lynn Tham, Manuel Bruch, Tania Narancic, Kevin O' Connor, Colm Ryan

Proteomics· October 2025

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Synthetic lethality in cancer drug discovery: challenges and opportunities.
Emanuel Gonçalves, Colm J Ryan, David J Adams

Nat Rev Drug Discov· September 2025

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A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening.
Victoria Harle, Victoria Offord, Birkan Gökbağ, Lazaros Fotopoulos, Thomas Williams, Colm J Ryan

Genome Biol· September 2025

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Benchmarking genetic interaction scoring methods for identifying synthetic lethality from combinatorial CRISPR screens.
Hamda Ajmal, Sutanu Nandi, Narod Kebabci, Colm J Ryan

NAR Genom Bioinform· September 2025

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Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer.
Anjan Venkatesh, Niall Quinn, Swathi Ramachandra Upadhya, Barbara De Kegel, Alfonso Bolado Carrancio, Colm J Ryan

Mol Syst Biol· August 2025

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The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.
Pui Ying Chan, Diana Alexander, Ishan Mehta, Larissa Satiko Alcantara Sekimoto Matsuyama, Victoria Harle, Colm J Ryan

Nat Genet· July 2025

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Evaluating sequence and structural similarity metrics for predicting shared paralog functions.
Olivier Dennler, Colm J Ryan

NAR Genom Bioinform· June 2025

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Hardware-efficient quantum error correction via concatenated bosonic qubits.
Harald Putterman, Kyungjoo Noh, Connor T Hann, Gregory S MacCabe, Shahriar Aghaeimeibodi, Colm A Ryan

Nature· February 2025

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Paralog dispensability shapes homozygous deletion patterns in tumor genomes.
Barbara De Kegel, Colm J Ryan

Mol Syst Biol· December 2023

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Gene essentiality in cancer is better predicted by mRNA abundance than by gene regulatory network-inferred activity.
Cosmin Tudose, Jonathan Bond, Colm J Ryan

NAR Cancer· December 2023

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Complex synthetic lethality in cancer.
Colm J Ryan, Lovely Paul Solomon Devakumar, Stephen J Pettitt, Christopher J Lord

Nat Genet· December 2023

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Exploiting Cancer Synthetic Lethality in Cancer-Lessons Learnt from PARP Inhibitors.
Stephen J Pettitt, Colm J Ryan, Christopher J Lord

Cancer Treat Res· November 2023

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Antibody reliability influences observed mRNA-protein correlations in tumour samples.
Swathi Ramachandra Upadhya, Colm J Ryan

Life Sci Alliance· August 2023

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Targeting synthetic lethal paralogs in cancer.
Colm J Ryan, Ishan Mehta, Narod Kebabci, David J Adams

Trends Cancer· May 2023

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Genetic interactions under the microscope.
Colm J Ryan

Cell Syst· May 2023

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Experimental reproducibility limits the correlation between mRNA and protein abundances in tumor proteomic profiles.
Swathi Ramachandra Upadhya, Colm J Ryan

Cell Rep Methods· September 2022

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Proteomic signatures of radioresistance: Alteration of inflammation, angiogenesis and metabolism-related factors in radioresistant oesophageal adenocarcinoma.
Simone Marcone, Amy Buckley, Colm J Ryan, Mark McCabe, Niamh Lynam-Lennon

Cancer Treat Res Commun· December 2021

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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines.
Barbara De Kegel, Niall Quinn, Nicola A Thompson, David J Adams, Colm J Ryan

Cell Syst· December 2021

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Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.
Andrey A Parkhitko, Arashdeep Singh, Sharon Hsieh, Yanhui Hu, Richard Binari, Colm J Ryan

PLoS Genet· February 2021

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Accurate prediction of kinase-substrate networks using knowledge graphs.
Vít Nováček, Gavin McGauran, David Matallanas, Adrián Vallejo Blanco, Piero Conca, Colm J Ryan

PLoS Comput Biol· December 2020

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Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.
Christopher J Lord, Niall Quinn, Colm J Ryan

Elife· May 2020

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Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS.
Susan A Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Colm J Ryan

Nat Commun· January 2020

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Paralog buffering contributes to the variable essentiality of genes in cancer cell lines.
Barbara De Kegel, Colm J Ryan

PLoS Genet· October 2019

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Cells Lacking the Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.
Matthew G Oser, Raquel Fonseca, Abhishek A Chakraborty, Rachel Brough, Alexander Spektor, Colm J Ryan

Cancer Discov· February 2019

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