Publications by authors named "Crystal McKnight"

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An Assessment of Kinase Selectivity, Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors.
Ana Corrionero, Xiaohu Zhang, Patricia Alfonso, Patrick J Morris, Carleen Klumpp-Thomas, Crystal McKnight

ACS Pharmacol Transl Sci· December 2025

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Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization.
Eric J Vick, Aishlin Hassan, Kwangmin Choi, Joshua Bennett, Tomoya Muto, Crystal McKnight

Leukemia· September 2025

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Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7-Expressing CRPC Models.
Benjamin C Brim, Andres F Leon, Erica L Beatson, Jessica D Kindrick, Kinjal Bhadresha, Crystal McKnight

Cancer Res Commun· August 2025

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Large-scale human myeloma cell line small molecule compound screen dataset.
V Keith Hughitt, John K Simmons, Sayeh Gorjifard, Aleksandra Michalowski, Kelli Wilson, Crystal McKnight

Sci Data· April 2025

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Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity.
Michele Ceribelli, Frances Anne Tosto, Xiaohu Zhang, Christopher J Melani, Mark Roschewski, Crystal McKnight

Proc Natl Acad Sci U S A· December 2024

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Castrate-resistant prostate cancer response to taxane is determined by an HNF1-dependent apoptosis resistance circuit.
Ilya S Senatorov, Joel Bowman, Keith H Jansson, Aian Neil Alilin, Brian J Capaldo, Crystal Mcknight

Cell Rep Med· December 2024

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Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts.
Yasuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Crystal McKnight

Cancer Res Commun· March 2024

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Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma.
Tyler J Peat, Snehal M Gaikwad, Wendy Dubois, Nana Gyabaah-Kessie, Shuling Zhang, Crystal McKnight

Cancer Lett· August 2023

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Preclinical Evaluation of the FGFR-Family Inhibitor Futibatinib for Pediatric Rhabdomyosarcoma.
Jerry T Wu, Adam Cheuk, Kristine Isanogle, Christina Robinson, Xiaohu Zhang, Crystal McKnight

Cancers (Basel)· August 2023

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High-throughput approaches to uncover synergistic drug combinations in leukemia.
Emma J Chory, Meng Wang, Michele Ceribelli, Aleksandra M Michalowska, Stefan Golas, Crystal McKnight

SLAS Discov· June 2023

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A landscape of response to drug combinations in non-small cell lung cancer.
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A Friedman, Arnaud Amzallag, Crystal McKnight

Nat Commun· June 2023

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Preclinical validation of a novel therapeutic strategy for choroid plexus carcinoma.
Brice Martin, Tyler Garman, Madeline Laramee, Amy Wang, Xiaohu Zhang, Crystal McKnight

J Control Release· May 2023

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Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Crystal McKnight

ACS Pharmacol Transl Sci· May 2023

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High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma.
Martin Lang, Laura S Schmidt, Kelli M Wilson, Christopher J Ricketts, Carole Sourbier, Crystal McKnight

J Exp Clin Cancer Res· April 2023

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mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer.
Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V Keith Hughitt, Xiaohu Zhang, Crystal McKnight

JCI Insight· March 2023

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Publisher Correction: Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.
Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Crystal McKnight

Nat Commun· October 2022

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Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.
Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Crystal McKnight

Nat Commun· September 2022

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Overcoming Acquired Epigenetic Resistance to BTK Inhibitors.
Arthur L Shaffer, James D Phelan, James Q Wang, DaWei Huang, George W Wright, Crystal McKnight

Blood Cancer Discov· November 2021

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Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.
Anish Thomas, Nobuyuki Takahashi, Vinodh N Rajapakse, Xiaohu Zhang, Yilun Sun, Crystal McKnight

Cancer Cell· April 2021

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Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening.
Grant L Lin, Kelli M Wilson, Michele Ceribelli, Benjamin Z Stanton, Pamelyn J Woo, Crystal McKnight

Sci Transl Med· November 2019

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High-Throughput Screening for Drug Combinations.
Paul Shinn, Lu Chen, Marc Ferrer, Zina Itkin, Carleen Klumpp-Thomas, Crystal McKnight

Methods Mol Biol· July 2019

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High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.
Sarah Wang, Elizabeth E Hwang, Rajarshi Guha, Allison F O'Neill, Nicole Melong, Crystal McKnight

Clin Cancer Res· July 2019

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A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma.
Lillian M Guenther, Neekesh V Dharia, Linda Ross, Amy Conway, Amanda L Robichaud, Crystal G McKnight

Clin Cancer Res· February 2019

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High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.
Keith H Jansson, John B Tucker, Lauren E Stahl, John K Simmons, Caitlyn Fuller, Crystal McKnight

Sci Rep· November 2018

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