Publications by authors named "Curtis Lam"

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Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Rafal Dolot, Curtis H Lam, Malgorzata Sierant, Qiang Zhao, Feng-Wu Liu

Nucleic Acids Res· May 2018

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X-Aptamer Selection and Validation.
Ganesh L Lokesh, Hongyu Wang, Curtis H Lam, Varatharasa Thiviyanathan, Nancy Ward

Methods Mol Biol· April 2018

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Selection of PD1/PD-L1 X-Aptamers.
Hongyu Wang, Curtis H Lam, Xin Li, Derek L West, Xianbin Yang

Biochimie· February 2018

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A densely modified M-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover.
Yajun Wang, Erkai Liu, Curtis H Lam, David M Perrin

Chem Sci· February 2018

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Whole cell-SELEX of aptamers with a tyrosine-like side chain against live bacteria.
Marleen Renders, Emily Miller, Curtis H Lam, David M Perrin

Org Biomol Chem· March 2017

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Systematic study of constraints imposed by modified nucleoside triphosphates with protein-like side chains for use in in vitro selection.
Yajun Wang, Nicole Ng, Erkai Liu, Curtis H Lam, David M Perrin

Org Biomol Chem· January 2017

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Synthesis and Enzymatic Incorporation of Modified Deoxyuridine Triphosphates.
Erkai Liu, Curtis H Lam, David M Perrin

Molecules· July 2015

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Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates.
Marcel Hollenstein, Christopher J Hipolito, Curtis H Lam, David M Perrin

ACS Comb Sci· April 2013

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A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain.
Curtis H Lam, Christopher J Hipolito, Marcel Hollenstein, David M Perrin

Org Biomol Chem· October 2011

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Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes.
Christopher J Hipolito, Marcel Hollenstein, Curtis H Lam, David M Perrin

Org Biomol Chem· April 2011

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In vitro selection of a DNAzyme with three modified nucleotides.
Marcel Hollenstein, Christopher Hipolito, Curtis Lam, David Perrin

Nucleic Acids Symp Ser (Oxf)· November 2010

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Introduction of guanidinium-modified deoxyuridine into the substrate binding regions of DNAzyme 10-23 to enhance target affinity: implications for DNAzyme design.
Curtis H Lam, David M Perrin

Bioorg Med Chem Lett· September 2010

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A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage.
Marcel Hollenstein, Christopher J Hipolito, Curtis H Lam, David M Perrin

Chembiochem· August 2009

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A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+).
Marcel Hollenstein, Christopher J Hipolito, Curtis H Lam, David M Perrin

Nucleic Acids Res· April 2009

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A highly selective DNAzyme sensor for mercuric ions.
Marcel Hollenstein, Christopher Hipolito, Curtis Lam, David Dietrich, David M Perrin

Angew Chem Int Ed Engl· July 2008

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